采用大口径毛细管气液色谱法及氮选择性检测法测定氟康唑。
Assay of fluconazole by megabore capillary gas-liquid chromatography with nitrogen-selective detection.
作者信息
Harris S C, Wallace J E, Foulds G, Rinaldi M G
机构信息
Laboratory Service, Audie L. Murphy Memorial Veterans' Hospital, San Antonio, Texas.
出版信息
Antimicrob Agents Chemother. 1989 May;33(5):714-6. doi: 10.1128/AAC.33.5.714.
Abstract
A megabore column gas-liquid chromatographic method which uses nitrogen-phosphorus detection was developed for the analysis of fluconazole in plasma, serum, cerebrospinal fluid, or urine. The assay was linear from 0.2 to 200 micrograms/ml and had an average coefficient of variation of 7%. The suitability of the assay for pharmacokinetic studies was demonstrated.
摘要
建立了一种采用氮磷检测的大口径柱气液色谱法，用于分析血浆、血清、脑脊液或尿液中的氟康唑。该测定法在0.2至200微克/毫升范围内呈线性，平均变异系数为7%。证明了该测定法适用于药代动力学研究。
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