• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Assay of fluconazole by megabore capillary gas-liquid chromatography with nitrogen-selective detection.采用大口径毛细管气液色谱法及氮选择性检测法测定氟康唑。
Antimicrob Agents Chemother. 1989 May;33(5):714-6. doi: 10.1128/AAC.33.5.714.
2
Determination of SCH 39304 by megabore capillary gas-liquid chromatography.
J Anal Toxicol. 1994 Mar-Apr;18(2):118-21. doi: 10.1093/jat/18.2.118.
3
Determination of fluconazole in biological fluids by capillary column gas chromatography with a nitrogen detector.
J Pharm Sci. 1988 Jun;77(6):534-5. doi: 10.1002/jps.2600770615.
4
Rapid and sensitive assay for fluconazole which uses gas chromatography with electron capture detection.采用带电子捕获检测的气相色谱法对氟康唑进行快速灵敏的检测。
Antimicrob Agents Chemother. 1992 Mar;36(3):647-50. doi: 10.1128/AAC.36.3.647.
5
Gas chromatographic method for the determination of fluconazole, a novel antifungal agent, in human plasma and urine.
J Chromatogr. 1986 Nov 28;383(1):179-86. doi: 10.1016/s0378-4347(00)83458-1.
6
Gas chromatographic and high-performance liquid chromatographic methods for the determination of genaconazole in biological fluids.气相色谱法和高效液相色谱法测定生物流体中的吉纳康唑
J Chromatogr B Biomed Appl. 1994 Apr 22;655(1):21-6. doi: 10.1016/0378-4347(94)00063-8.
7
Gas chromatographic assay of vigabatrin enantiomers in plasma.
J Chromatogr. 1993 Jun 23;616(1):39-44. doi: 10.1016/0378-4347(93)80469-k.
8
Assay of fluconazole by high-performance liquid chromatography with a mixed-phase column.采用混合相柱高效液相色谱法测定氟康唑。
Antimicrob Agents Chemother. 1992 Mar;36(3):603-6. doi: 10.1128/AAC.36.3.603.
9
High-performance liquid chromatographic and megabore gas-liquid chromatographic determination of levetiracetam (ucb L059) in human serum after solid-phase extraction.
J Chromatogr B Biomed Appl. 1994 Dec 2;662(1):134-9. doi: 10.1016/0378-4347(94)00393-9.
10
Megabore capillary gas-liquid chromatographic method with nitrogen-phosphorus selective detection for the assay of haloperidol and reduced haloperidol in serum: results of therapeutic drug-monitoring during acute therapy of eight schizophrenics.
J Chromatogr B Biomed Appl. 1995 Jan 20;663(2):289-96. doi: 10.1016/0378-4347(94)00463-f.

引用本文的文献

1
Correlation of the in vitro antifungal drug susceptibility with the in vivo activity of fluconazole in a murine model of cerebral infection caused by Cryptococcus gattii.隐球菌性脑膜炎的动物模型中氟康唑的体外抗真菌药敏与体内活性的相关性研究。
Eur J Clin Microbiol Infect Dis. 2010 Dec;29(12):1525-32. doi: 10.1007/s10096-010-1034-8. Epub 2010 Aug 28.
2
Monitoring and impact of fluconazole serum and cerebrospinal fluid concentration in HIV-associated cryptococcal meningitis-infected patients.监测和评估 HIV 相关隐球菌性脑膜炎感染患者氟康唑血清和脑脊液浓度的影响。
HIV Med. 2010 Apr;11(4):276-81. doi: 10.1111/j.1468-1293.2009.00778.x. Epub 2009 Dec 8.
3
Effect of high-dose fluconazole on QT interval in patients with human immunodeficiency virus (HIV)-associated cryptococcal meningitis.大剂量氟康唑对人类免疫缺陷病毒（HIV）相关隐球菌性脑膜炎患者QT间期的影响。
Int J Antimicrob Agents. 2009 Nov;34(5):494-6. doi: 10.1016/j.ijantimicag.2009.05.009. Epub 2009 Jun 30.
4
Effect of calcineurin inhibitors on posaconazole blood levels as measured by the MVista microbiological assay.通过MVista微生物学测定法测量钙调神经磷酸酶抑制剂对泊沙康唑血药浓度的影响。
Antimicrob Agents Chemother. 2008 Feb;52(2):730-1. doi: 10.1128/AAC.01096-07. Epub 2007 Nov 19.
5
Neonatal coinfection model of coagulase-negative Staphylococcus (Staphylococcus epidermidis) and Candida albicans: fluconazole prophylaxis enhances survival and growth.凝固酶阴性葡萄球菌（表皮葡萄球菌）与白色念珠菌的新生儿混合感染模型：氟康唑预防可提高生存率并促进生长。
Antimicrob Agents Chemother. 2007 Apr;51(4):1240-5. doi: 10.1128/AAC.01298-06. Epub 2007 Jan 29.
6
Characterization and quantitation of the pharmacodynamics of fluconazole in a neutropenic murine disseminated candidiasis infection model.在中性粒细胞减少小鼠播散性念珠菌病感染模型中氟康唑药效学的表征与定量分析
Antimicrob Agents Chemother. 1999 Sep;43(9):2116-20. doi: 10.1128/AAC.43.9.2116.
7
Effect of route of administration of fluconazole on the interaction between fluconazole and midazolam.氟康唑给药途径对氟康唑与咪达唑仑相互作用的影响。
Eur J Clin Pharmacol. 1997;51(5):415-9. doi: 10.1007/s002280050223.
8
Clinical pharmacokinetics of fluconazole.氟康唑的临床药代动力学
Clin Pharmacokinet. 1993 Jan;24(1):10-27. doi: 10.2165/00003088-199324010-00002.
9
Pharmacokinetics and bioavailability of fluconazole in patients with AIDS.氟康唑在艾滋病患者中的药代动力学和生物利用度。
Antimicrob Agents Chemother. 1993 Oct;37(10):2187-92. doi: 10.1128/AAC.37.10.2187.
10
Pharmacokinetics of fluconazole in pediatric patients.
Eur J Clin Microbiol Infect Dis. 1994 Apr;13(4):325-9. doi: 10.1007/BF01974613.

本文引用的文献

1
Further in vitro studies with 5-fluorocytosine.进一步的氟胞嘧啶体外研究。
Infect Immun. 1970 Oct;2(4):484-8. doi: 10.1128/iai.2.4.484-488.1970.
2
Laboratory evaluation of antifungal agents: a comparative study of five imidazole derivatives of clinical importance.抗真菌药物的实验室评估：五种具有临床重要性的咪唑衍生物的比较研究。
J Antimicrob Chemother. 1980 Nov;6(6):749-61. doi: 10.1093/jac/6.6.749.
3
The prevalence of yeasts in clinical specimens from cancer patients.癌症患者临床标本中酵母菌的患病率。
Am J Clin Pathol. 1980 Apr;73(4):518-21. doi: 10.1093/ajcp/73.4.518.
4
Minimal concentrations of aminoglycoside that can synergize with penicillin in enterococcal endocarditis.在肠球菌性心内膜炎中可与青霉素协同作用的氨基糖苷类药物的最低浓度。
Antimicrob Agents Chemother. 1981 Sep;20(3):405-9. doi: 10.1128/AAC.20.3.405.
5
Enhancement of the in vitro activity of amphotericin B against Aspergillus spp. by tetracycline analogs.四环素类似物增强两性霉素B对曲霉属真菌的体外活性。
Antimicrob Agents Chemother. 1984 Dec;26(6):837-40. doi: 10.1128/AAC.26.6.837.
6
Effect of antineoplastic agents on the growth and ultrastructure of Candida albicans.抗肿瘤药物对白色念珠菌生长和超微结构的影响。
Mykosen. 1984 Sep;27(9):452-64. doi: 10.1111/j.1439-0507.1984.tb02060.x.
7
Interactions among amphotericin B, 5-fluorocytosine, ketoconazole, and miconazole against pathogenic fungi in vitro.两性霉素B、5-氟胞嘧啶、酮康唑和咪康唑在体外对致病真菌的相互作用。
Antimicrob Agents Chemother. 1982 Nov;22(5):763-70. doi: 10.1128/AAC.22.5.763.
8
Antifungal action of amphotericin B in combination with other polyene or imidazole antibiotics.两性霉素B与其他多烯类或咪唑类抗生素联合使用时的抗真菌作用。
J Infect Dis. 1982 Aug;146(2):138-46. doi: 10.1093/infdis/146.2.138.
9
Synergistic action of amphotericin B and rifampin on Candida albicans.两性霉素B与利福平对白色念珠菌的协同作用。
Am Rev Respir Dis. 1974 Nov;110(5):671-3. doi: 10.1164/arrd.1974.110.5.671.
10
Oral monilia study on patients with head and neck cancer during radiotherapy.头颈部癌患者放疗期间口腔念珠菌研究
Cancer. 1974 Aug;34(2):246-9. doi: 10.1002/1097-0142(197408)34:2<246::aid-cncr2820340203>3.0.co;2-j.

采用大口径毛细管气液色谱法及氮选择性检测法测定氟康唑。

Assay of fluconazole by megabore capillary gas-liquid chromatography with nitrogen-selective detection.

作者信息

Harris S C, Wallace J E, Foulds G, Rinaldi M G

机构信息

Laboratory Service, Audie L. Murphy Memorial Veterans' Hospital, San Antonio, Texas.

出版信息

Antimicrob Agents Chemother. 1989 May;33(5):714-6. doi: 10.1128/AAC.33.5.714.

DOI:10.1128/AAC.33.5.714
PMID:2546489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC172520/
Abstract

A megabore column gas-liquid chromatographic method which uses nitrogen-phosphorus detection was developed for the analysis of fluconazole in plasma, serum, cerebrospinal fluid, or urine. The assay was linear from 0.2 to 200 micrograms/ml and had an average coefficient of variation of 7%. The suitability of the assay for pharmacokinetic studies was demonstrated.

摘要

建立了一种采用氮磷检测的大口径柱气液色谱法，用于分析血浆、血清、脑脊液或尿液中的氟康唑。该测定法在0.2至200微克/毫升范围内呈线性，平均变异系数为7%。证明了该测定法适用于药代动力学研究。