Wallace J E, Harris S C, Gallegos J, Foulds G, Chen T J, Rinaldi M G
Department of Pathology, University of Texas Health Science Center, San Antonio 78284-7750.
Antimicrob Agents Chemother. 1992 Mar;36(3):603-6. doi: 10.1128/AAC.36.3.603.
A mixed-phase liquid chromatographic column was used to assay fluconazole in plasma, serum, and cerebrospinal fluid. The assay was linear from 0.2 to 20 micrograms/ml, with an average coefficient of variation of less than 5%. The partitioning of the drug between serum and cerebrospinal fluid was determined for 34 patients. The method was demonstrated to be suitable for both pharmacokinetic studies and monitoring of patients receiving treatment with this antifungal agent.
