一项关于结肠镜检查低容量肠道准备方法的疗效和耐受性的随机前瞻性试验。
A randomized, prospective trial on efficacy and tolerability of low-volume bowel preparation methods for colonoscopy.
作者信息
Yoo In Kyung, Lee Jong Soo, Chun Hoon Jai, Jeen Yoon Tae, Keum Bora, Kim Eun Sun, Choi Hyuk Soon, Lee Jae Min, Kim Seung Han, Nam Seung Joo, Kang Hyo Sung, Lee Hong Sik, Kim Chang Duck, Um Soon Ho, Seo Yeon Seok, Ryu Ho Sang
机构信息
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Korea University College of Medicine, Seoul, Republic of Korea.
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Korea University College of Medicine, Seoul, Republic of Korea.
出版信息
Dig Liver Dis. 2015 Feb;47(2):131-7. doi: 10.1016/j.dld.2014.10.019. Epub 2014 Nov 4.
BACKGROUND
Low-volume bowel preparations have been shown to provide an equivalent cleansing effect as that of a standard 4 L polyethylene glycol. However, studies comparing the efficacy of low-volume bowel preparations are few, and the results have been controversial. This study aimed to compare the bowel cleansing quality and tolerability between sodium picosulfate/magnesium citrate and polyethylene glycol with ascorbic acid.
METHODS
A randomized study was performed with two hundred outpatients who were prospectively enrolled. The Boston Bowel Preparation Scale and the Aronchick scale were used to evaluate the bowel cleansing quality, and bubble scoring was also performed to back up both results. To investigate patients' preferences and tolerability, a questionnaire was administered.
RESULTS
Sodium picosulfate/magnesium citrate was not inferior to polyethylene glycol with ascorbic acid in terms of successful bowel preparation (≥ 6 Boston scale score: 80% vs. 82%; p = 0.718, adequate Aronchick grade: 93% vs. 96%; p = 0.352). In addition, sodium picosulfate/magnesium citrate caused fewer gastrointestinal symptoms, and tasted better than polyethylene glycol with ascorbic acid.
CONCLUSIONS
Sodium picosulfate/magnesium citrate was not inferior to polyethylene glycol with ascorbic acid in cleansing efficacy, and was found to have higher tolerability.
背景
低容量肠道准备已被证明能提供与标准4升聚乙二醇相当的清洁效果。然而，比较低容量肠道准备效果的研究较少，且结果存在争议。本研究旨在比较比沙可啶钠/枸橼酸镁与含抗坏血酸的聚乙二醇之间的肠道清洁质量和耐受性。
方法
对200名前瞻性招募的门诊患者进行了一项随机研究。使用波士顿肠道准备量表和阿隆奇克量表评估肠道清洁质量，并进行气泡评分以支持这两个结果。为了调查患者的偏好和耐受性，发放了一份问卷。
结果
在成功的肠道准备方面（波士顿量表评分≥6分：80%对82%；p = 0.718，阿隆奇克分级足够：93%对96%；p = 0.352），比沙可啶钠/枸橼酸镁并不逊于含抗坏血酸的聚乙二醇。此外，比沙可啶钠/枸橼酸镁引起的胃肠道症状较少，且味道比含抗坏血酸的聚乙二醇更好。
结论
比沙可啶钠/枸橼酸镁在清洁效果上并不逊于含抗坏血酸的聚乙二醇，且耐受性更高。
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