Cumeras R, Figueras E, Davis C E, Baumbach J I, Gràcia I
Institut de Microelectrònica de Barcelona, IMB-CNM (CSIC), Esfera UAB, Campus UAB s/n, E-08193 Bellaterra, Barcelona, Spain.
Analyst. 2015 Mar 7;140(5):1376-90. doi: 10.1039/c4an01100g.
Ion Mobility Spectrometry (IMS) is a widely used and 'well-known' technique of ion separation in the gaseous phase based on the differences in ion mobilities under an electric field. All IMS instruments operate with an electric field that provides space separation, but some IMS instruments also operate with a drift gas flow that provides also a temporal separation. In this review we will summarize the current IMS instrumentation. IMS techniques have received an increased interest as new instrumentation and have become available to be coupled with mass spectrometry (MS). For each of the eight types of IMS instruments reviewed it is mentioned whether they can be hyphenated with MS and whether they are commercially available. Finally, out of the described devices, the six most-consolidated ones are compared. The current review article is followed by a companion review article which details the IMS hyphenated techniques (mainly gas chromatography and mass spectrometry) and the factors that make the data from an IMS device change as a function of device parameters and sampling conditions. These reviews will provide the reader with an insightful view of the main characteristics and aspects of the IMS technique.
离子迁移谱（IMS）是一种广泛应用且“广为人知”的气相离子分离技术，它基于电场作用下离子迁移率的差异来实现分离。所有的IMS仪器都通过提供空间分离的电场来运行，但一些IMS仪器还通过提供时间分离的漂移气流来运行。在这篇综述中，我们将总结当前的IMS仪器设备。随着新仪器设备的出现，IMS技术受到了越来越多的关注，并且已可与质谱（MS）联用。对于所综述的八种类型的IMS仪器，文中均提及了它们是否可与MS联用以及是否有商业产品。最后，对所描述的设备中的六种最成熟的设备进行了比较。紧随这篇综述文章之后的是一篇配套综述文章，该文章详细介绍了IMS联用技术（主要是气相色谱和质谱）以及使IMS设备的数据随设备参数和采样条件而变化的因素。这些综述将为读者提供对IMS技术的主要特点和方面的深刻见解。
