Schumacher M, Coirini H, McEwen B S
Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021.
Brain Res. 1989 May 15;487(1):178-83. doi: 10.1016/0006-8993(89)90955-4.
The effects of estradiol benzoate (EB) and of progesterone (P) treatment on high-affinity [3H]muscimol binding in the dorsal hippocampal formation were examined in ovariectomized and adrenalectomized female rats by in vitro autoradiography. EB injected subcutaneously increased [3H]muscimol binding in specific subregions of the Ammon's horn (CA1 and stratum radiatum of CA4) and of the dentate gyrus (dorsal molecular layer). In these particular regions, estrogen receptors have been shown to be present. P did not significantly affect [3H]muscimol binding in any region of the hippocampus when administered alone or in combination with EB. Results suggest that estrogens may regulate the activity of specific hippocampal neurons by modulating their sensitivity to GABA.
通过体外放射自显影技术，研究了苯甲酸雌二醇（EB）和孕酮（P）处理对去卵巢和肾上腺切除的雌性大鼠背侧海马结构中高亲和力[3H]蝇蕈醇结合的影响。皮下注射EB可增加海马角特定亚区（CA1和CA4的辐射层）以及齿状回（背侧分子层）的[3H]蝇蕈醇结合。在这些特定区域，已证明存在雌激素受体。单独给予P或与EB联合给予时，P对海马的任何区域的[3H]蝇蕈醇结合均无显著影响。结果表明，雌激素可能通过调节特定海马神经元对γ-氨基丁酸（GABA）的敏感性来调节其活性。
