Ultrastructural features that relate to tumor cell behaviour in human breast carcinomas.

Human breast tumor biopsies were studied by transmission electron microscopy for ultrastructural characteristics that might be associated with tumor cell function and behaviour. Features related to the state of cell differentiation and tumor cell detachment were evaluated and discussed. The ultrastructure of loose cells at the tumor periphery is compared with that of coherent cells in interior regions. Structural information has been analysed by taking into account available biochemical data for interpretation of cell function. The value of the parameters chosen for study is discussed. This study shows that each tumor needs to be evaluated independently for its specific ultrastructural features. Electron microscopic data becomes more relevant when interpreted in conjunction with histological diagnosis and clinical findings.