Yoon Mi Young, Lee Keehoon, Yoon Sang Sun
Department of Microbiology and Immunology, Yonsei University College of Medicine, Seoul, 120-752, Republic of Korea.
J Microbiol. 2014 Dec;52(12):983-9. doi: 10.1007/s12275-014-4655-2. Epub 2014 Nov 29.
The human gastrointestinal tract is colonized by multitudes of microorganisms that exert beneficial effects on human health. Mounting evidence suggests that intestinal microbiota contributes to host resistance against enteropathogenic bacterial infection. However, molecular details that account for such an important role has just begun to be understood. The commensal microbes in the intestine regulate gut homeostasis through activating the development of host innate immunity and producing molecules with antimicrobial activities that directly inhibit propagation of pathogenic bacteria. Understanding the protective roles of gut microbiota will provide a better insight into the molecular basis that underlies complicated interaction among host-pathogen-symbiont. In this review, we highlighted recent findings that help us broaden our knowledge of the intestinal ecosystem and thereby come up with a better strategy for combating enteropathogenic infection.
人类胃肠道中定殖着大量微生物，它们对人类健康发挥着有益作用。越来越多的证据表明，肠道微生物群有助于宿主抵抗肠道病原菌感染。然而，解释这一重要作用的分子细节才刚刚开始被了解。肠道中的共生微生物通过激活宿主固有免疫的发育和产生具有抗菌活性的分子来直接抑制病原菌的繁殖，从而调节肠道稳态。了解肠道微生物群的保护作用将有助于更好地洞察宿主-病原体-共生体之间复杂相互作用的分子基础。在这篇综述中，我们重点介绍了最近的研究发现，这些发现有助于拓宽我们对肠道生态系统的认识，从而提出更好的策略来对抗肠道病原菌感染。
