Payne Samuel H
Pacific Northwest National Laboratory, 902 Battelle Boulevard, Richland, WA 99354, USA.
Trends Biochem Sci. 2015 Jan;40(1):1-3. doi: 10.1016/j.tibs.2014.10.010. Epub 2014 Nov 23.
Transcriptomic, proteomic, and metabolomic measurements are revolutionizing the way we model and predict cellular behavior, and multi-omic comparisons are being published with increased regularity. Some have expected a trivial and predictable correlation between mRNA and protein; however, the manifest complexity of biological regulation suggests a more nuanced relationship. Indeed, observing this lack of strict correlation provides clues for new research topics, and has the potential for transformative biological insight.
转录组学、蛋白质组学和代谢组学测量正在彻底改变我们对细胞行为进行建模和预测的方式，多组学比较的发表频率也在不断增加。有些人曾预期mRNA和蛋白质之间存在简单且可预测的相关性；然而，生物调节明显的复杂性表明两者之间的关系更为微妙。事实上，观察到这种缺乏严格相关性为新的研究课题提供了线索，并有潜力带来变革性的生物学见解。
