Rom O, Karkabi K, Reznick A Z, Keidar Z, Aizenbud D
Department of Anatomy and Cell Biology, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Adv Exp Med Biol. 2015;849:49-56. doi: 10.1007/5584_2014_92.
The objective of this study was to investigate the relationship between smoking history expressed by pack-years, metabolic and inflammatory markers, parameters of body composition (BC) and muscle strength among heavy smokers. A detailed smoking history was obtained from 49 heavy smokers (age = 44 ± 12, pack-years = 31 ± 23). Blood samples were analyzed for levels of glucose, lipids, liver enzymes and C-reactive protein (CRP). Anthropometric measurements included waist circumference and assessment of BC by dual energy X-ray absorptiometry (DEXA) and bioelectrical impedance analysis (BIA). Muscle strength was assessed by handgrip dynamometry and predicted one-repetition maximum (p1RM) tests. Positive correlations were found between pack-years of smoking, fasting glucose, alkaline phosphatase and CRP levels. Pack-years were also positively correlated with waist circumference, body mass index (BMI), whole-body and trunk fat mass measured by both DEXA and BIA. A negative correlation was found between pack-years of smoking and muscle strength measured by p1RM for the leg press exercise. After adjustment for age, sex and BMI, a positive correlation remained between pack-years of smoking and CRP levels. In conclusion, after controlling for possible confounders, smoking history was found to be positively associated with CRP levels among heavy smokers.
本研究的目的是调查重度吸烟者中以吸烟包年数表示的吸烟史、代谢和炎症标志物、身体成分（BC）参数与肌肉力量之间的关系。从49名重度吸烟者（年龄=44±12岁，吸烟包年数=31±23）获取了详细的吸烟史。对血液样本进行了葡萄糖、脂质、肝酶和C反应蛋白（CRP）水平分析。人体测量包括腰围以及通过双能X线吸收法（DEXA）和生物电阻抗分析（BIA）评估身体成分。通过握力测力法和预测的一次重复最大值（p1RM）测试评估肌肉力量。发现吸烟包年数与空腹血糖、碱性磷酸酶和CRP水平之间存在正相关。吸烟包年数与腰围、体重指数（BMI）、通过DEXA和BIA测量的全身及躯干脂肪量也呈正相关。发现吸烟包年数与腿部推举运动的p1RM测量的肌肉力量之间存在负相关。在对年龄、性别和BMI进行调整后，吸烟包年数与CRP水平之间仍存在正相关。总之，在控制了可能的混杂因素后，发现吸烟史与重度吸烟者的CRP水平呈正相关。
