Effect of Smokeless Tobacco (Maras Powder) on the Epicardial Fat Thickness and Ventricular Repolarization Parameters.

: Smokeless tobacco (ST) use has recently become an alternative to cigarettes, and it has been concluded that ST is at least as harmful as cigarettes. ST use is thought to play a role in the pathogenesis of arrhythmia by affecting ventricular repolarization. In this study, we aimed to examine the relationships of Maras powder (MP), one of the ST varieties, with epicardial fat thickness and new ventricular repolarization parameters, which have not previously been described. : A total of 289 male individuals were included in this study between April 2022 and December 2022. Three groups, 97 MP users, 97 smokers, and 95 healthy (non-tobacco), were compared according to electrocardiographic and echocardiographic data. Electrocardiograms (ECG) were evaluated with a magnifying glass by two expert cardiologists at a speed of 50 m/s. Epicardial fat thickness (EFT) was measured by echocardiography in the parasternal short- and long-axis images. A model was created with variables that could affect epicardial fat thickness. : There were no differences between the groups regarding body mass index ( = 0.672) and age ( = 0.306). The low-density lipoprotein value was higher in the MP user group ( = 0.003). The QT interval was similar between groups. Tp-e ( = 0.022), cTp-e ( = 0.013), Tp-e/QT ( =0.005), and Tp-e/cQT ( = 0.012) were higher in the MP user group. While the Tp-e/QT ratio did not affect EFT, MP predicted the epicardial fat thickness ( < 0.001, B = 0.522, 95%CI 0.272-0.773). : Maras powder may play a role in ventricular arrhythmia by affecting EFT and causing an increase in the Tp-e interval.