Department of Public Health, University of Helsinki, Helsinki, Finland; Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland.
Department of Public Health, University of Helsinki, Helsinki, Finland; Hospital District of Southwest Finland and Turku University Hospital, Turku, Finland; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.
Prev Med Rep. 2016 Jul 11;4:324-30. doi: 10.1016/j.pmedr.2016.07.003. eCollection 2016 Dec.
Several studies have reported direct associations of smoking with body mass index (BMI) and abdominal obesity. However, the interplay between them is poorly understood. Our first aim was to investigate the interaction between smoking status and BMI on abdominal obesity (waist circumference, WC). Our second aim was to examine how the association of smoking status with WC varies among normal and overweight/obese men and women. We examined 5833 participants from the National FINRISK 2007 Study. The interactions between smoking and BMI on WC were analyzed. Participants were categorized into eight groups according to BMI (normal weight vs. overweight/obese) and smoking status (never smoker, ex-smoker, occasional/light/moderate daily smoker, heavy daily smoker). The associations between each BMI/smoking status -group and WC were analyzed by multiple regressions, the normal-weight never smokers as the reference group. The smoking status by BMI-interaction on WC was significant for women, but not for men. Among the overweight/obese women, ex-smokers (β = 2.73; 1.99, 3.46) and heavy daily smokers (β = 4.90; 3.35, 6.44) had the highest estimates for WC when adjusted for age, BMI, alcohol consumption and physical activity. In comparison to never smoking overweight/obese women, the β-coefficients of ex-smokers and heavy daily smokers were significantly higher. Among men and normal weight women the β -coefficients did not significantly differ by smoking status. An interaction between smoking status and BMI on abdominal obesity was observed in women: overweight/obese heavy daily smokers were particularly vulnerable for abdominal obesity. This risk group should be targeted for cardiovascular disease prevention.
多项研究报告了吸烟与体重指数（BMI）和腹部肥胖之间的直接关联。然而，它们之间的相互作用仍知之甚少。我们的首要目标是调查吸烟状况与 BMI 对腹部肥胖（腰围，WC）的相互作用。我们的第二个目标是研究吸烟状况与 WC 的关联在正常体重和超重/肥胖男性和女性中的变化。我们检查了来自全国 FINRISK 2007 研究的 5833 名参与者。分析了吸烟状况和 BMI 对 WC 的相互作用。根据 BMI（正常体重与超重/肥胖）和吸烟状况（从不吸烟者、前吸烟者、偶尔/轻度/中度每日吸烟者、重度每日吸烟者）将参与者分为八组。通过多元回归分析每个 BMI/吸烟状况组与 WC 的关系，以正常体重从不吸烟者为参考组。在女性中，吸烟状况与 BMI 的相互作用对 WC 有显著影响，但在男性中没有。在超重/肥胖的女性中，与从不吸烟的超重/肥胖女性相比，前吸烟者（β=2.73；1.99，3.46）和重度每日吸烟者（β=4.90；3.35，6.44）的 WC 估计值最高，调整了年龄、BMI、饮酒和身体活动。与从不吸烟的超重/肥胖女性相比，前吸烟者和重度每日吸烟者的β系数明显更高。对于男性和正常体重女性，吸烟状况的β系数没有显著差异。在女性中观察到吸烟状况和 BMI 对腹部肥胖的相互作用：超重/肥胖的重度每日吸烟者尤其容易患腹部肥胖。应针对该高危人群进行心血管疾病预防。
