Laban Mohamed, Mansour Ghada M, Elsafty Mohammed S E, Hassanin Alaa S, EzzElarab Sahar S
Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Int J Gynaecol Obstet. 2015 Mar;128(3):246-50. doi: 10.1016/j.ijgo.2014.09.018. Epub 2014 Nov 15.
To develop reference cutoff values for mean fetal lung volume (FLV) and pulmonary artery resistance index (PA-RI) for prediction of neonatal respiratory distress syndrome (RDS) in low-risk term pregnancies.
As part of a cross-sectional study, women aged 20-35 years were enrolled and admitted to a tertiary hospital in Cairo, Egypt, for elective repeat cesarean at 37-40 weeks of pregnancy between January 1, 2012, and July 31, 2013. FLV was calculated by virtual organ computer-aided analysis, and PA-RI was measured by Doppler ultrasonography before delivery.
A total of 80 women were enrolled. Neonatal RDS developed in 11 (13.8%) of the 80 newborns. Compared with neonates with RDS, healthy neonates had significantly higher FLVs (P<0.001) and lower PA-RIs (P<0.001). Neonatal RDS is less likely with FLV of at least 32 cm(3) or PA-RI less than or equal to 0.74. Combining these two measures improved the accuracy of prediction.
The use of either FLV or PA-RI predicted neonatal RDS. The predictive value increased when these two measures were combined.
制定平均胎儿肺容积（FLV）和肺动脉阻力指数（PA-RI）的参考临界值，用于预测低风险足月妊娠新生儿呼吸窘迫综合征（RDS）。
作为一项横断面研究的一部分，选取年龄在20 - 35岁之间的女性，于2012年1月1日至2013年7月31日期间入住埃及开罗一家三级医院，在妊娠37 - 40周时进行择期重复剖宫产。分娩前通过虚拟器官计算机辅助分析计算FLV，采用多普勒超声测量PA-RI。
共纳入80名女性。80例新生儿中有11例（13.8%）发生新生儿RDS。与患RDS的新生儿相比，健康新生儿的FLV显著更高（P<0.001），PA-RI显著更低（P<0.001）。FLV至少为32 cm³或PA-RI小于或等于0.74时，新生儿发生RDS的可能性较小。将这两种测量方法结合可提高预测准确性。
使用FLV或PA-RI均可预测新生儿RDS。将这两种测量方法结合时，预测价值增加。
