Yasuzawa T, Saitoh Y, Sano H
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.
J Antibiot (Tokyo). 1990 Apr;43(4):336-43. doi: 10.7164/antibiotics.43.336.
The structures of KS-501 and KS-502, new inhibitors of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase, were determined to be 2-(beta-D-galactofuranosyloxy)-6-heptyl-4-hydroxybenzoic acid 3-heptyl-5-hydroxyphenyl ester and 2-(beta-D-galactofuranosyloxy)6-heptyl-4-hydroxybenzoic acid 4-carboxy-3-heptyl-5-hydroxyphenyl ester, respectively, on the basis of chemical and physico-chemical evidences.
基于化学和物理化学证据，确定钙和钙调蛋白依赖性环核苷酸磷酸二酯酶的新型抑制剂KS-501和KS-502的结构分别为2-(β-D-呋喃半乳糖氧基)-6-庚基-4-羟基苯甲酸3-庚基-5-羟基苯酯和2-(β-D-呋喃半乳糖氧基)6-庚基-4-羟基苯甲酸4-羧基-3-庚基-5-羟基苯酯。
