KS - 504化合物，来自风毛菌的新型钙离子和钙调蛋白依赖性环核苷酸磷酸二酯酶抑制剂。
KS-504 compounds, novel inhibitors of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase from Mollisia ventosa.
作者信息
Nakanishi S, Ando K, Kawamoto I, Yasuzawa T, Sano H, Kase H
机构信息
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.
出版信息
J Antibiot (Tokyo). 1989 Dec;42(12):1775-83. doi: 10.7164/antibiotics.42.1775.
Novel inhibitors of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase were isolated from the culture broth of a fungus, Mollisia ventosa KAC-1148. They were designated as KS-504a, KS-504b and KS-504d. A degradative product of KS-504a, called KS-504e, was also isolated and found to inhibit the enzyme. The 50% inhibitory concentration (IC50) values of KS-504a, KS-504b, KS-504d and KS-504e for bovine brain enzyme were 122, 109, greater than 500 and 139 microM, respectively.
新型钙（Ca2+）及钙调蛋白依赖性环核苷酸磷酸二酯酶抑制剂是从真菌Venturia ventosa KAC - 1148的培养液中分离得到的。它们被命名为KS - 504a、KS - 504b和KS - 504d。KS - 504a的一种降解产物KS - 504e也被分离出来，并且发现它能抑制该酶。KS - 504a、KS - 504b、KS - 504d和KS - 504e对牛脑酶的50%抑制浓度（IC50）值分别为122、109、大于500和139微摩尔。
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