Seyyed-Mohammadzad Mir Hossein, Khademvatani Kamal, Kerachian Abdollah, Eskandari Ramin, Rezaei Yousef
Department of Cardiology, Seyyed-al-Shohada Heart Center, Urmia University of Medical Sciences, Urmia, Iran.
Department of Cardiology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
Korean Circ J. 2014 Nov;44(6):400-5. doi: 10.4070/kcj.2014.44.6.400. Epub 2014 Nov 25.
We sought to determine the relationship between mean platelet volume (MPV), platelet distribution width (PDW), and platelet larger cell ratio (P-LCR) with slow coronary flow (SCF).
Eighty participants who underwent coronary angiography were divided into two groups, 50 participants with SCF as case group, and 30 with normal coronary flow (NCF) as control group. Baseline characteristics and laboratory data were collected before angiography.
Platelet volume indices MPV (10.8±1.2 fL), PDW (14.5±2.2 fL), and P-LCR (30.5±8.1%) in the SCF group were significantly (p<0.05) higher than those (10.1±0.9 fL, 13.2±1.8 fL, and 26.8±6.8%, respectively) in the NCF group. The patients with three SCF arteries had significantly higher platelet volume indices compared to those with NCF arteries; however, the patients with one SCF artery did not. Based on linear regression model, MPV, PDW, and P-LCR were independent predictors of mean infarction frame counting (TFC). In multivariate analysis, MPV {odds ratio (OR)=32.393, 95% confidence interval (CI)=1.189-882.606, p=0.039} and P-LCR (OR=0.566, 95% CI=0.330-0.937, p=0.028) were independent predictors of SCF.
Platelet volume indices MPV, PDW, and P-LCR were associated with both the presence and extent of SCF.
我们试图确定平均血小板体积（MPV）、血小板分布宽度（PDW）和血小板大细胞比率（P-LCR）与冠状动脉血流缓慢（SCF）之间的关系。
80例行冠状动脉造影的参与者被分为两组，50例冠状动脉血流缓慢者作为病例组，30例冠状动脉血流正常（NCF）者作为对照组。在血管造影术前收集基线特征和实验室数据。
SCF组的血小板体积指标MPV（10.8±1.2 fL）、PDW（14.5±2.2 fL）和P-LCR（30.5±8.1%）显著（p<0.05）高于NCF组（分别为10.1±0.9 fL、13.2±1.8 fL和26.8±6.8%）。三支冠状动脉血流缓慢的患者血小板体积指标显著高于冠状动脉血流正常的患者；然而，单支冠状动脉血流缓慢的患者则不然。基于线性回归模型，MPV、PDW和P-LCR是平均梗死帧数（TFC）的独立预测因素。在多变量分析中，MPV{比值比（OR）=32.393，95%置信区间（CI）=1.189 - 882.606，p=0.039}和P-LCR（OR=0.566，95%CI=0.330 - 0.937，p=0.028）是SCF的独立预测因素。
血小板体积指标MPV、PDW和P-LCR与SCF的存在及程度均相关。
