Department of Cardiology, Balikesir University, School of Medicine, Balikesir, Turkey.
Cardiol J. 2012;19(4):355-62. doi: 10.5603/cj.2012.0065.
Slow coronary flow (SCF) is characterized by delayed opacification of epicardial coronary vessels. SCF can cause ischemia and sudden cardiac death. We investigated the association between presence and extent of SCF, and cardiovascular risk factors and hematologic indices.
In this study, 2467 patients who received coronary angiography for suspected or known ischemic heart disease were retrospectively evaluated between April 2009 and November 2010. Following the application of exclusion criteria, our study population consisted of 57 SCF patients (experimental group) and 90 patients with age- and gender-matched subjects who proved to have normal coronary angiograms (control group). Baseline hematologic indices were measured by the automated complete blood count (CBC) analysis. The groups were evaluated for cardiovascular risk factors and medications. Patients were categorized based on the angiographic findings of vessels with or without SCF. Moreover, patients with SCF were divided into subgroups relative to the extent of SCF.
Among the 147 patients (mean age 52.7 ± 10.0, 53.7% male), mean platelet volume (MPV) ranged from 6.5 fL to 11.7 fL (median 7.9 fL, mean 8.1 ± 0.8 fL). Diabetes (OR = 3.64, 95% CI 1.15-10.43, p = 0.03), hypercholesterolemia (OR = 4.94, 95% CI 1.99-12.21, p = 0.001), smoking (OR = 3.54, 95% CI 1.43-8.72, p = 0.006), hemoglobin (OR = 1.69, 95% CI 1.22-2.36, p = 0.002), and MPV (OR = 2.52, 95% CI 1.43-4.44, p = 0.001) were found to be the independent correlates of SCF presence. Only MPV (OR = 2.13, 95% CI 1.05-4.33, p = 0.03) was identified as an independent correlate of extent of SCF.
Elevated baseline MPV value was found to be an independent predictor of the presence and extent of SCF.
慢血流（SCF）的特征是心外膜冠状动脉血管显影延迟。SCF 可导致缺血和心源性猝死。我们研究了 SCF 的存在和程度与心血管危险因素和血液学指标之间的关系。
本研究回顾性分析了 2009 年 4 月至 2010 年 11 月间因疑似或已知缺血性心脏病而行冠状动脉造影的 2467 例患者。排除标准后，本研究纳入了 57 例 SCF 患者（实验组）和 90 例年龄和性别匹配的冠状动脉造影正常的患者（对照组）。采用全自动全血细胞计数（CBC）分析测量基线血液学指标。评估了心血管危险因素和药物治疗情况。根据有无 SCF 的血管造影结果对患者进行分类。此外，根据 SCF 的程度将患者分为亚组。
在 147 例患者（平均年龄 52.7±10.0 岁，53.7%为男性）中，平均血小板体积（MPV）范围为 6.5 至 11.7 fL（中位数为 7.9 fL，平均为 8.1±0.8 fL）。糖尿病（OR=3.64，95%CI 1.15-10.43，p=0.03）、高胆固醇血症（OR=4.94，95%CI 1.99-12.21，p=0.001）、吸烟（OR=3.54，95%CI 1.43-8.72，p=0.006）、血红蛋白（OR=1.69，95%CI 1.22-2.36，p=0.002）和 MPV（OR=2.52，95%CI 1.43-4.44，p=0.001）是 SCF 存在的独立相关因素。只有 MPV（OR=2.13，95%CI 1.05-4.33，p=0.03）被确定为 SCF 程度的独立相关因素。
基础 MPV 值升高被发现是 SCF 存在和程度的独立预测因子。
