Wang Weijie, Zhang Yujiao, Gao Mei, Wang Jiangrong, Hou Yinglong
Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China ; Department of ICU, People's Hospital of Rizhao, Rizhao, Shandong 276826, P.R. China.
Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China ; School of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China.
Biomed Rep. 2015 Jan;3(1):78-82. doi: 10.3892/br.2014.366. Epub 2014 Sep 26.
The present study aimed to investigate the effect of rosuvastatin on atrial structural remodeling in rabbits with myocardial infarction (MI). The rabbits were randomly divided into 4 groups: The sham operation group (S; n=8), the MI group (MI; n=7), the group with low-dose rosuvastatin [R; 2.5 mg/(kg/d), n=7] and the group with high-dose rosuvastatin [R, 5 mg/(kg/d), n=8]. A rabbit MI model was established via ligation of the anterior descending coronary artery. After 8 weeks of intervention, the left atrial diameter (LAD), atrial collagen content, expression level of type I collagen and left ventricular ejection fraction (LVEF) were measured. LAD in the MI group was significantly larger than the S, R and R groups after 8 weeks. The left atrial collagen content of the MI group was also significantly greater than those observed in the other 3 groups. The expression of type I collagen in the MI group was significantly increased compared to the other 3 groups. However, LVEF of the MI group was lower compared to the other 3 groups. There were no significant differences between the R and R groups in the above indexes. In conclusion, rosuvastatin can improve post-MI atrial structural remodeling.
本研究旨在探讨瑞舒伐他汀对心肌梗死（MI）家兔心房结构重塑的影响。将家兔随机分为4组：假手术组（S；n = 8）、MI组（MI；n = 7）、低剂量瑞舒伐他汀组[R；2.5 mg/(kg/d)，n = 7]和高剂量瑞舒伐他汀组[R，5 mg/(kg/d)，n = 8]。通过结扎冠状动脉前降支建立家兔MI模型。干预8周后，测量左心房直径（LAD）、心房胶原含量、I型胶原表达水平和左心室射血分数（LVEF）。8周后，MI组的LAD显著大于S组、R组和R组。MI组的左心房胶原含量也显著高于其他3组。与其他3组相比，MI组I型胶原的表达显著增加。然而，MI组的LVEF低于其他3组。R组和R组在上述指标上无显著差异。综上所述，瑞舒伐他汀可改善心肌梗死后的心房结构重塑。
