Ma Limin, Liu Hongchao, Ruan Linhai, Yang Xuewen, Yang Haiping, Feng Yanming
Department of Hematology, The First Affiliated Hospital, Luoyang, Henan 471003, P.R. China.
Medical College, Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China.
Biomed Rep. 2015 Jan;3(1):83-87. doi: 10.3892/br.2014.387. Epub 2014 Nov 14.
Several studies have investigated the association between multidrug resistance gene () C1236T polymorphism and leukemia risk, however, these published studies have yielded conflicting results. Thus, the present study carried out a meta-analysis to provide a more precise estimate of the effect of this polymorphism on the susceptibility to leukemia. The published case-control studies regarding the association between C1236T polymorphism and leukemia risk were included following a computerized search of PubMed, Elsevier, The Cochrane Library, China National Knowledge Infrastructure and Wanfang Database. Either fixed- or random-effects models were applied to calculate the combined odds ratios (ORs) and 95% confidence intervals (CIs) by RevMan 5.2 software. Seven studies, including 846 cases and 1,523 controls, were included in the present meta-analysis. The results indicated that there was no significant association between the C1236T polymorphism and leukemia risk in overall comparisons in all four genetic models (CT vs. CC: OR, 1.31, 95% CI, 0.89-1.91, P=0.17; TT vs. CC: OR, 2.16, 95% CI, 0.99-4.70, P=0.05; TT vs. CC+CT: OR, 1.72, 95% CI, 0.91-3.25, P=0.09; and CT+TT vs. CC: OR, 1.57, 95% CI, 0.96-2.56, P=0.07). In the subgroup analysis according to specific ethnicity, age and the type of leukemia, a significant association was found in adult leukemia (CT+TT vs. CC: OR, 2.77, 95% CI, 1.05-7.31, P=0.04) and chronic myeloid leukemia (CT vs. CC: OR, 1.71, 95% CI, 1.05-2.80, P=0.03). No significant publication bias was detected by funnel plot. Therefore, the meta-analysis indicated that the C1236T polymorphism may contribute to the susceptibility to adult leukemia and chronic myeloid leukemia. Furthe well-designed studies based on larger sample sizes are required to validate these findings.
多项研究调查了多药耐药基因（）C1236T多态性与白血病风险之间的关联，然而，这些已发表的研究结果相互矛盾。因此，本研究进行了一项荟萃分析，以更精确地估计这种多态性对白血病易感性的影响。通过对PubMed、Elsevier、Cochrane图书馆、中国知网和万方数据库进行计算机检索，纳入了已发表的关于C1236T多态性与白血病风险关联的病例对照研究。使用RevMan 5.2软件应用固定效应或随机效应模型来计算合并比值比（OR）和95%置信区间（CI）。本荟萃分析纳入了7项研究，包括846例病例和1523例对照。结果表明，在所有四种遗传模型的总体比较中，C1236T多态性与白血病风险之间无显著关联（CT vs. CC：OR，1.31，95%CI，0.89 - 1.91，P = 0.17；TT vs. CC：OR，2.16，95%CI，0.99 - 4.70，P = 0.05；TT vs. CC + CT：OR，1.72，95%CI，0.91 - 3.25，P = 0.09；CT + TT vs. CC：OR，1.57，95%CI，0.96 - 2.56，P = 0.07）。在根据特定种族、年龄和白血病类型进行的亚组分析中，在成人白血病（CT + TT vs. CC：OR，2.77，95%CI，1.05 - 7.31，P = 0.04）和慢性髓性白血病（CT vs. CC：OR，1.71，95%CI，1.05 - 2.80，P = 0.03）中发现了显著关联。漏斗图未检测到显著的发表偏倚。因此，荟萃分析表明C1236T多态性可能与成人白血病和慢性髓性白血病的易感性有关。需要进一步基于更大样本量的精心设计研究来验证这些发现。
