CEBPE基因rs2239633多态性与儿童急性淋巴细胞白血病易感性的关系：一项更新的荟萃分析。
The CEBPE rs2239633 genetic polymorphism on susceptibility to childhood acute lymphoblastic leukemia: an updated meta-analysis.
作者信息
Liu Jin, Weiling Gu, Xueqin Li, Liang Xie, Linhong Wang, Zhongwen Chen
机构信息
Department of Control and Prevention of Chronic Non-communicable Diseases, Jiaxing Center for Disease Control and Prevention, Jiaxing, Zhejiang, 314050, China.
Office, Jiaxing Center for Disease Control and Prevention, No.486 Wenqiao Road, Jiaxing, Zhejiang, 314050, China.
出版信息
Environ Health Prev Med. 2021 Jan 4;26(1):2. doi: 10.1186/s12199-020-00920-2.
OBJECTIVES
We performed an updated meta-analysis to clarify the relationship between the CEBPE rs2239633 polymorphism and the childhood acute lymphoblastic leukemia (CALL) susceptibility.
METHODS
All the case-control studies were updated on October 5, 2020, through Web of Science, PubMed, Cochrane Library, Embase, and China National Knowledge Infrastructure (CNKI) electronic database. The heterogeneity in the study was tested by the Q test and I, and then the random ratio or fixed effect was utilized to merge the odds ratios (OR) and 95% confidence interval (CI). We also performed sensitivity analysis to estimate the impact of individual studies on aggregate estimates. Publication bias was investigated by using funnel plot and Egger's regression test. All statistical analyses were performed using Stata 12.0.
RESULTS
A total of 20 case-control studies were selected, including 7014 patients and 16,428 controls. There was no association of CEBPE rs2239633 polymorphism with CALL (CC vs CT + TT: OR = 1.08, 95% CI = 0.94-1.26; CC + CT vs TT: OR = 1.10, 95% CI = 0.94-1.30; C vs T: OR = 1.02, 95% CI = 0.92-1.13). In the subgroup analysis by ethnicity, there is no significant association of this polymorphism and CALL risks among Asian and Caucasian populations in the three genetic models (CC vs CT + TT, CC + CT vs TT, and C vs T).
CONCLUSION
This meta-analysis found no significant association between the CEBPE rs2239633 polymorphism and susceptibility to CALL.
目的
我们进行了一项更新的荟萃分析，以阐明CEBPE基因rs2239633多态性与儿童急性淋巴细胞白血病（CALL）易感性之间的关系。
方法
通过Web of Science、PubMed、Cochrane图书馆、Embase和中国知网（CNKI）电子数据库，于2020年10月5日更新了所有病例对照研究。采用Q检验和I²检验研究中的异质性，然后利用随机效应模型或固定效应模型合并比值比（OR）和95%置信区间（CI）。我们还进行了敏感性分析，以评估个体研究对总体估计值的影响。采用漏斗图和Egger回归检验研究发表偏倚。所有统计分析均使用Stata 12.0软件进行。
结果
共纳入20项病例对照研究，包括7014例患者和16428例对照。CEBPE基因rs2239633多态性与CALL无关联（CC与CT + TT比较：OR = 1.08，95%CI = 0.94 - 1.26；CC + CT与TT比较：OR = 1.10，95%CI = 0.94 - 1.30；C与T比较：OR = 1.02，95%CI = 0.92 - 1.13）。在按种族进行的亚组分析中，在三种遗传模型（CC与CT + TT、CC + CT与TT、C与T）中，该多态性与亚洲和白种人群中CALL风险均无显著关联。
结论
这项荟萃分析发现CEBPE基因rs2239633多态性与CALL易感性之间无显著关联。
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