血清甲胎蛋白在卵巢卵黄囊瘤中的预后价值：一项系统评价和荟萃分析
Prognostic value of serum α-fetoprotein in ovarian yolk sac tumors: A systematic review and meta-analysis.
作者信息
Guo Yang-Long, Zhang Ying-Li, Zhu Jian-Qing
机构信息
Department of Gynecologic Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China.
出版信息
Mol Clin Oncol. 2015 Jan;3(1):125-132. doi: 10.3892/mco.2014.417. Epub 2014 Sep 18.
This study was conducted to determine the prognostic value of serum α-fetoprotein (AFP) levels in patients with ovarian yolk sac tumor (OYST). We performed a systematic review and meta-analysis to assess the associations between serum AFP level and prognosis in OYST. A total of 12 quantitative studies met the inclusion criteria. Preoperative AFP was not found to be associated with overall survival (OS) [odds ratio (OR)=0.84, 95% confidence interval (CI): 0.43-1.62] in OYST. However, a high postoperative AFP level was associated with worse OS (OR=0.16, 95% CI: 0.05-0.48) and relapse-free survival (RFS) (OR=0.18, 95% CI: 0.08-0.43) compared to a low postoperative AFP level in patients with OYST. In addition, a postoperative AFP level of >1,000 ng/ml was associated with a decrease in OS (OR=0.16, 95% CI: 0.05-0.50) and RFS (OR=0.21, 95% CI: 0.08-0.57). In conclusion, the postoperative, but not the preoperative, AFP level was found to be a prognostic factor in patients with OYST. In particular, a postoperative AFP level of >1,000 ng/ml was an indicator of poor prognosis in patients with OYST.
本研究旨在确定血清甲胎蛋白（AFP）水平对卵巢卵黄囊瘤（OYST）患者的预后价值。我们进行了一项系统评价和荟萃分析，以评估血清AFP水平与OYST预后之间的关联。共有12项定量研究符合纳入标准。未发现术前AFP与OYST患者的总生存期（OS）相关[比值比（OR）=0.84，95%置信区间（CI）：0.43 - 1.62]。然而，与OYST患者术后低AFP水平相比，术后高AFP水平与较差的OS（OR=0.16，95%CI：0.05 - 0.48）和无复发生存期（RFS）（OR=0.18，95%CI：0.08 - 0.43）相关。此外，术后AFP水平>1000 ng/ml与OS（OR=0.16，95%CI：0.05 - 0.50）和RFS（OR=0.21，95%CI：0.08 - 0.57）降低相关。总之，发现术后而非术前AFP水平是OYST患者的一个预后因素。特别是，术后AFP水平>1000 ng/ml是OYST患者预后不良的一个指标。
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