Ishiguro T, Yoshida Y, Tenzaki T, Ohshima M, Suzuki H
Cancer. 1981 Dec 1;48(11):2480-4. doi: 10.1002/1097-0142(19811201)48:11<2480::aid-cncr2820481122>3.0.co;2-8.
Serial serum alpha-fetoprotein (AFP) was examined postoperatively in five patients with yolk sac tumor and in three with solid teratoma of the ovary. Serial estimation of AFP was also done in sera from postpartum patients to compare the decreasing ratio between the two groups. Serum AFP in these postpartum women decreased according to the exponential function curve as AFP = be-mx (x = days after delivery) with a mean m value of 0.1652 and a mean correlation coefficient of -0.9911. Half-time of serum AFP in postpartum subjects was 4.33 days. Exponential decrease of serum AFP was also found in postoperative patients with yolk sac tumor and solid teratoma of the ovary. However, in those in whom there was an incomplete removal of the tumors, the values of either m or coefficient of correlation were significantly lower as compared to those in patients with complete extirpation of lesions or those in postpartum subjects. Elevation of serum AFP was noted postoperatively in two patients with recurrences; however, significant decreases in AFP following chemotherapy were apparent in one patient with immature solid teratoma. These findings suggest that the decreasing ratio of postoperative serum AFP is an effective indicator to determine whether or not the lesions were completely extirpated, although a normal value may not always imply the absence of microscopic metastasis of tumor cells. Serial estimation of serum AFP was of value in assessing the presence of recurrences and evaluating the efficacy of chemotherapy.
对5例卵黄囊瘤患者和3例卵巢实性畸胎瘤患者术后进行了连续血清甲胎蛋白（AFP）检测。还对产后患者的血清进行了AFP连续测定，以比较两组之间的下降率。这些产后女性的血清AFP按照指数函数曲线下降，即AFP = be - mx（x = 分娩后天数），平均m值为0.1652，平均相关系数为 - 0.9911。产后受试者血清AFP的半衰期为4.33天。在卵巢卵黄囊瘤和实性畸胎瘤术后患者中也发现血清AFP呈指数下降。然而，在肿瘤切除不完全的患者中，m值或相关系数与病变完全切除的患者或产后受试者相比显著更低。两名复发患者术后血清AFP升高；然而，一名未成熟实性畸胎瘤患者化疗后AFP明显下降。这些发现表明，术后血清AFP的下降率是判断病变是否完全切除的有效指标，尽管正常数值并不总是意味着不存在肿瘤细胞的微小转移。血清AFP连续测定对于评估复发情况和评价化疗疗效具有价值。
