Gardiner Joseph C, Reed Philip L, Bonner Joseph D, Haggerty Diana K, Hale Daniel G
Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA.
Clinical and Translational Sciences Institute, Michigan State University, East Lansing, MI, USA.
Int Wound J. 2016 Oct;13(5):809-20. doi: 10.1111/iwj.12386. Epub 2014 Dec 3.
Our study sought to estimate the association between race, gender, comorbidity and body mass index (BMI) on the incidence of hospital-acquired pressure ulcer (PU) from a population-based retrospective cohort comprising 242 745 unique patient hospital discharges in two fiscal years from July 2009 to June 2010 from 15 general and tertiary care hospitals. Cases were patients with a single inpatient encounter that led to an incident PU. Controls were patients without a PU at any encounter during the two fiscal years with the earliest admission retained for analysis. Logistic regression models quantified the association of potential risk factors for PU incidence. Spline functions captured the non-linear effects of age and comorbidity. Overall 2·68% of patients experienced an incident PU during their inpatient stay. Unadjusted analyses revealed statistically significant associations by age, gender, race, comorbidity, BMI, admitted for a surgical procedure, source of admission and fiscal year, but differences by gender and race did not persist in adjusted analyses. Interactions between age, comorbidity and BMI contributed significantly to the likelihood of PU incidence. Patients who were older, with multiple comorbidities and admitted for a surgical diagnosis-related groups (DRG) were at greater risk of experiencing a PU during their stay.
我们的研究旨在从一个基于人群的回顾性队列中,估计种族、性别、合并症和体重指数(BMI)与医院获得性压疮(PU)发生率之间的关联。该队列包含2009年7月至2010年6月这两个财政年度内,来自15家综合医院和三级护理医院的242745例独特的患者出院记录。病例为单次住院期间发生了新发PU的患者。对照为在这两个财政年度内,任何一次住院期间均未发生PU的患者,并保留最早入院记录用于分析。逻辑回归模型对PU发生的潜在风险因素的关联进行了量化。样条函数捕捉了年龄和合并症的非线性效应。总体而言,2.68%的患者在住院期间发生了新发PU。未经调整的分析显示,年龄、性别、种族、合并症、BMI、因外科手术入院、入院来源和财政年度之间存在统计学上的显著关联,但在调整分析中,性别和种族差异不再存在。年龄、合并症和BMI之间的相互作用对PU发生的可能性有显著影响。年龄较大、患有多种合并症且因外科诊断相关分组(DRG)入院的患者,在住院期间发生PU的风险更高。