Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, Brig. S.K. Mazumdar Road, Timarpur, Delhi-110054, India.
Curr Drug Deliv. 2014;11(6):771-91. doi: 10.2174/156720181106141202122335.
Development of colloidal delivery systems has opened new avenues/frontiers for improving drug delivery. Solid lipid nanoparticles have come up as the latest development in the arena of lipid based colloidal delivery systems after nanoemulsion and liposomes ever since their introduction in the early 1990s. In this review, the authors have made efforts to bring forth the essential and practically relevant aspects of SLNs. This review gives an overview of the preparation methods of solid lipid nanoparticles while mainly focussing on their biological applications including their projected applications in drug delivery. This review critically examines the influential factors governing the formation of SLNs and then discussing in detail the several techniques being utilized for their characterization. This review discusses the drug loading and drug release aspects of SLNs as these are useful biocompatible carriers of lipophilic and to a certain extent hydrophilic drugs. An updated list of drugs encapsulated into various lipids to prepare SLN formulations has been provided. Other relevant aspects pertaining to the clinical use of SLN formulations like their sterilization and storage stability have also been explained. A unique facet of this review is the discussion on the challenging issues of in vivo applications and recent progresses in overcoming these challenges which follows in the end.
胶态递药系统的发展为改善药物递释开辟了新的途径/领域。自 20 世纪 90 年代初问世以来，固体脂质纳米粒已成为继纳米乳剂和脂质体之后脂质基胶态递药系统领域的最新进展。在这篇综述中，作者努力阐述了 SLNs 的基本和实际相关方面。本综述概述了固体脂质纳米粒的制备方法，主要集中在其生物应用，包括其在药物递释中的预期应用。本综述批判性地考察了影响 SLNs 形成的因素，然后详细讨论了用于其表征的几种技术。本综述讨论了 SLNs 的载药和释药方面，因为它们是亲脂性和在一定程度上亲水药物的有用的生物相容性载体。提供了已封装到各种脂质中以制备 SLN 制剂的药物的更新列表。还解释了与 SLN 制剂的临床应用相关的其他相关方面，例如其灭菌和储存稳定性。本综述的一个独特方面是讨论了体内应用的挑战性问题以及最近在克服这些挑战方面的进展。
