Liu Chunmei, Shi Erbo, Xu Feng, Luo Qiang, Wang Hongxiang, Chen Jijun, Wan Xiaobing
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Renai Road, 215123 Suzhou, China.
Chem Commun (Camb). 2015 Jan 25;51(7):1214-7. doi: 10.1039/c4cc07833k.
A novel strategy has been developed for the highly chemo- and stereo-selective synthesis of (Z)-β-perfluoroalkyl enaminones from readily available starting materials via a multicomponent radical reaction involving sequential fluoroalkylation and Kornblum-DeLaMare reaction. Notably, this methodology involves the concurrent cleavage of at least three chemical bonds, including two C-F bonds and one C-X (X = Br or I) bond, as well as the formation of three new bonds, including one C=O bond, one C=C bond and one C-N bond, in one pot.
