Luo Qiang, Liu Chunmei, Tong Jingjing, Shao Ying, Shan Wenyu, Wang Hanghang, Zheng Hao, Cheng Jiang, Wan Xiaobing
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, P. R. China.
Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Advanced Catalysis and Green Manufacturing Collaborative Innovation Center, Changzhou University , Changzhou, 213164, P. R. China.
J Org Chem. 2016 Apr 15;81(8):3103-11. doi: 10.1021/acs.joc.5b02664. Epub 2016 Mar 25.
An efficient synthesis of Z-perfluoroalkyl-substituted enones by a multicomponent reaction strategy has been described. A variety of elusive perfluoroalkylated enones are furnished under mild reaction conditions in good yields with unique chemo- and stereoselectivity. A sequence of radical-mediated Kornblum-DeLaMare reaction, Michael addition, and HF elimination is proposed for the mechanism.
已描述了通过多组分反应策略高效合成Z-全氟烷基取代的烯酮。在温和的反应条件下，以良好的产率和独特的化学及立体选择性提供了各种难以捉摸的全氟烷基化烯酮。该反应机理被认为是由自由基介导的Kornblum-DeLaMare反应、迈克尔加成和HF消除组成的序列。
