Atluru D, Goodwin J S
Am J Vet Res. 1986 Sep;47(9):1963-6.
Leukotriene (LT) B4, a 5-lipoxygenase metabolite of arachidonic acid, is a potent inducer of suppressor cells in phytohemagglutinin-stimulated cultures of bovine peripheral blood mononuclear cells. In contrast, LTC4 and LTD4 have little activity. Incubation of T lymphocytes with LTB4 at concentrations as low as 1 X 10(-12)M rendered these lymphocytes suppressive of [3H]thymidine incorporation in subsequent phytohemagglutinin-stimulated cultures of fresh autologous lymphocytes. This LTB4-induced cell was radiosensitive to irradiation at 2,000 rads. Leukotriene B4 may have an important part in immunoregulation during hypersensitivity reactions.
白三烯（LT）B4是花生四烯酸的5-脂氧合酶代谢产物，在植物血凝素刺激的牛外周血单核细胞培养物中是抑制细胞的强效诱导剂。相比之下，LTC4和LTD4的活性很小。用低至1×10⁻¹²M浓度的LTB4孵育T淋巴细胞，会使这些淋巴细胞在随后植物血凝素刺激的新鲜自体淋巴细胞培养物中抑制[³H]胸腺嘧啶核苷掺入。这种LTB4诱导的细胞对2000拉德的辐射敏感。白三烯B4可能在超敏反应期间的免疫调节中起重要作用。
