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月见草油对正在接受异维A酸治疗的痤疮患者预防干性唇炎的作用：一项初步研究。

The effect of evening primrose oil for the prevention of xerotic cheilitis in acne patients being treated with isotretinoin: a pilot study.

作者信息

Park Kui Young, Ko Eun Jung, Kim In Su, Li Kapsok, Kim Beom Joon, Seo Seong Jun, Kim Myeung Nam, Hong Chang Kwun

机构信息

Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.

出版信息

Ann Dermatol. 2014 Dec;26(6):706-12. doi: 10.5021/ad.2014.26.6.706. Epub 2014 Nov 26.

DOI:10.5021/ad.2014.26.6.706
PMID:25473222
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4252667/
Abstract

BACKGROUND

The most common adverse effects of oral isotretinoin are cheilitis, skin dryness, dry eyes, and conjunctivitis, whereas evening primrose oil (EPO) is known to improve skin moisture and transepidermal water loss (TEWL) in healthy adults and atopic patients.

OBJECTIVE

To evaluate the clinical efficacy and safety of EPO in preventing xerotic cheilitis in acne patients being treated with oral isotretinoin.

METHODS

Forty Korean volunteers of Fitzpatrick skin types III and IV, having moderate acne, were enrolled and randomized to receive either isotretinoin with or without EPO for 8 weeks. The efficacy of treatment was evaluated on the basis of global acne grading system scores, number of inflammatory and noninflammatory lesions, TEWL, corneometry, physician's global assessment, and patient satisfaction.

RESULTS

The results after 8 weeks of treatment showed that the TEWL of the lip increased significantly during isotretinoin treatment, whereas the TEWL of the hand dorsum showed no significant change. The increase of the TEWL of the lip was more definite in the control group than in the experimental group. The number of acne lesions decreased significantly in both groups, and there were no differences between them.

CONCLUSION

Our study suggests that the addition of EPO improved xerotic cheilitis in acne patients being treated with oral isotretinoin. However, besides TEWL and corneometry assessments, additional studies are required for a complete understanding of the role of EPO in xerotic cheilitis in acne patients being treated with oral isotretinoin.

摘要

背景

口服异维A酸最常见的不良反应是唇炎、皮肤干燥、干眼和结膜炎，而月见草油（EPO）已知可改善健康成年人及特应性患者的皮肤水分和经表皮水分流失（TEWL）。

目的

评估EPO在预防口服异维A酸治疗的痤疮患者干性唇炎方面的临床疗效和安全性。

方法

招募40名Fitzpatrick皮肤类型为III型和IV型、患有中度痤疮的韩国志愿者，随机分为接受异维A酸加或不加EPO治疗8周。根据整体痤疮分级系统评分、炎性和非炎性皮损数量、TEWL、角质层含水量测定、医生整体评估和患者满意度来评估治疗效果。

结果

治疗8周后的结果显示，异维A酸治疗期间唇部的TEWL显著增加，而手背的TEWL无显著变化。唇部TEWL的增加在对照组比实验组更明显。两组痤疮皮损数量均显著减少，且两组之间无差异。

结论

我们的研究表明，添加EPO可改善口服异维A酸治疗的痤疮患者的干性唇炎。然而，除了TEWL和角质层含水量测定评估外，还需要进一步研究以全面了解EPO在口服异维A酸治疗的痤疮患者干性唇炎中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f989/4252667/7c83ee4dc07a/ad-26-706-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f989/4252667/baf8100cedaa/ad-26-706-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f989/4252667/5284bddad04e/ad-26-706-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f989/4252667/dc97dee26c40/ad-26-706-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f989/4252667/7c83ee4dc07a/ad-26-706-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f989/4252667/baf8100cedaa/ad-26-706-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f989/4252667/5284bddad04e/ad-26-706-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f989/4252667/dc97dee26c40/ad-26-706-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f989/4252667/7c83ee4dc07a/ad-26-706-g004.jpg

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