Downey R S, Sewell C W, Mansour K A
Division of Thoracic and Cardiovascular Surgery, Joseph B. Whitehead Department of Surgery, Atlanta, Georgia.
Ann Thorac Surg. 1989 Jun;47(6):806-8. doi: 10.1016/0003-4975(89)90007-6.
A retrospective review was made of 96 consecutive patients with large cell carcinoma of the lung admitted to Emory University Hospital over 10 years. Only 10 patients were seen with stage I lesions favorable for resection. The remainder were treated primarily with irradiation or chemotherapy. Mean survival for clinical stage I patients was 15.9 months; stage IIIA patients, 7.9 months; stage IIIB patients, 7.1 months; and stage IV patients, 5.8 months. Only 1 patient survived for 5 years. This distinct and highly aggressive form of lung cancer most commonly is seen at an advanced stage and is associated with an unusually dismal prognosis regardless of the method of treatment employed.
对埃默里大学医院10年间收治的96例连续性肺大细胞癌患者进行了回顾性研究。仅10例患者为适合手术切除的Ⅰ期病变。其余患者主要接受放疗或化疗。临床Ⅰ期患者的平均生存期为15.9个月；ⅢA期患者为7.9个月；ⅢB期患者为7.1个月；Ⅳ期患者为5.8个月。仅1例患者存活了5年。这种独特且侵袭性很强的肺癌最常见于晚期，无论采用何种治疗方法，其预后都异常糟糕。
