微小RNA：炎症性肠病中的新角色。
MicroRNAs: new players in IBD.
作者信息
Kalla R, Ventham N T, Kennedy N A, Quintana J F, Nimmo E R, Buck A H, Satsangi J
机构信息
Gastrointestinal Unit, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.
Centre for Immunity, Infection and Evolution, Ashworth laboratories, University of Edinburgh, Edinburgh, UK.
出版信息
Gut. 2015 Mar;64(3):504-17. doi: 10.1136/gutjnl-2014-307891. Epub 2014 Dec 4.
MicroRNAs (miRNAs) are small non-coding RNAs, 18-23 nucleotides long, which act as post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the pathogenesis of many common diseases, including IBDs. This review aims to outline the history, biogenesis and regulation of miRNAs. The role of miRNAs in the development and regulation of the innate and adaptive immune system is discussed, with a particular focus on mechanisms pertinent to IBD and the potential translational applications.
微小RNA（miRNA）是长度为18 - 23个核苷酸的小型非编码RNA，它们作为基因表达的转录后调节因子发挥作用。miRNA与包括炎症性肠病（IBD）在内的许多常见疾病的发病机制密切相关。本综述旨在概述miRNA的历史、生物合成及调控。讨论了miRNA在先天性和适应性免疫系统发育及调控中的作用，特别关注与IBD相关的机制以及潜在的转化应用。
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