Madewell B R, Munn R J
Department of Veterinary Surgery, School of Veterinary Medicine, University of California, Davis 95616.
J Comp Pathol. 1989 May;100(4):449-52. doi: 10.1016/0021-9975(89)90011-x.
Abnormal irregularly branched and anastomosing tubules within cisternae of endoplasmic reticulum were observed by transmission electron microscopy in tumour cells comprising connective tissue neoplasms (sarcoids) from three horses and a mule. These tubuloreticular inclusions were also observed in cultured tumour cells from one of these horses examined, but were not detected in fibroblasts (fibrocytes), epidermis, or vascular endothelial cells in skin biopsy specimens from five clinically healthy horses, nor in one additional equine connective tissue neoplasm.
通过透射电子显微镜观察发现，在来自三匹马和一头骡子的结缔组织肿瘤（肉瘤样瘤）的肿瘤细胞中，内质网池内存在异常的不规则分支且相互吻合的小管。在其中一匹接受检查的马的培养肿瘤细胞中也观察到了这些管状网状包涵体，但在五匹临床健康马的皮肤活检标本中的成纤维细胞（纤维细胞）、表皮或血管内皮细胞中未检测到，在另外一例马结缔组织肿瘤中也未检测到。
