Papadopoulos A, Sioen I, Cubadda F, Ozer H, Basegmez H I Oktay, Turrini A, Lopez Esteban M T, Fernandez San Juan P M, Sokolić-Mihalak D, Jurkovic M, De Henauw S, Aureli F, Vin K, Sirot V
French Agency for Food, Environmental and Occupational Health Safety (ANSES, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail), 14, rue Pierre et Marie Curie, F-94701 Maisons-Alfort Cedex, France.
Department of Public Health, Universiteit Gent - Ghent University, UZ 2 Block A, De Pintelaan 185, B-9000 Gent, Belgium.
Food Chem Toxicol. 2015 Feb;76:46-53. doi: 10.1016/j.fct.2014.11.015. Epub 2014 Dec 2.
The objective of this article is to develop a general method based on the analytic hierarchy process (AHP) methodology to rank the substances to be studied in a Total Diet Studies (TDS). This method was tested for different substances and groups of substances (N = 113), for which the TDS approach has been considered relevant. This work was performed by a group of 7 experts from different European countries representing their institutes, which are involved in the TDS EXPOSURE project. The AHP methodology is based on a score system taking into account experts' judgments quantified assigning comparative scores to the different identified issues. Hence, the 10 substances of highest interest in the framework of a TDS are trace elements (methylmercury, cadmium, inorganic arsenic, lead, aluminum, inorganic mercury), dioxins, furans and polychlorinated biphenyls (PCBs), and some additives (sulfites and nitrites). The priority list depends on both the national situation (geographical variations, consumer concern, etc.) and the availability of data. Thus, the list depends on the objectives of the TDS and on reachable analytical performances. Moreover, such a list is highly variable with time and new data (e.g. social context, vulnerable population groups, emerging substances, new toxicological data or health-based guidance values).
本文的目的是开发一种基于层次分析法（AHP）的通用方法，用于对总膳食研究（TDS）中待研究的物质进行排名。该方法针对不同物质和物质组（N = 113）进行了测试，TDS方法被认为适用于这些物质和物质组。这项工作由来自不同欧洲国家的7位专家组成的团队完成，他们代表各自参与TDS暴露项目的机构。层次分析法基于一个评分系统，该系统考虑了专家的判断，通过为不同识别出的问题量化分配比较分数来实现。因此，在总膳食研究框架内最受关注的10种物质是微量元素（甲基汞、镉、无机砷、铅、铝、无机汞）、二噁英、呋喃和多氯联苯（PCBs），以及一些添加剂（亚硫酸盐和亚硝酸盐）。优先级列表既取决于国家情况（地理差异、消费者关注等），也取决于数据的可用性。因此，该列表取决于总膳食研究的目标和可达到 的分析性能。此外，这样的列表会随着时间和新数据（例如社会背景、弱势群体、新兴物质、新的毒理学数据或基于健康的指导值）而发生很大变化。
