精神分裂症患者死后脑区中[3H]MK - 801结合位点
[3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients.
作者信息
Kornhuber J, Mack-Burkhardt F, Riederer P, Hebenstreit G F, Reynolds G P, Andrews H B, Beckmann H
机构信息
Department of Psychiatry, University of Würzburg, Federal Republic of Germany.
出版信息
J Neural Transm. 1989;77(2-3):231-6. doi: 10.1007/BF01248936.
PMID:2547892
Abstract
[3H]MK-801 binding was used as a marker for the NMDA receptorion channel complex in postmortem brain samples from the frontal cortex, hippocampus, putamen, entorhinal region, and amygdala of schizophrenic patients and controls. In schizophrenia [3H]MK-801 binding levels were increased in all brain regions investigated reaching significance in the putamen.
摘要
[3H]MK-801结合被用作精神分裂症患者和对照者额叶皮质、海马体、壳核、内嗅区及杏仁核的死后脑样本中N-甲基-D-天冬氨酸（NMDA）受体离子通道复合物的标志物。在精神分裂症患者中，所有研究的脑区中[3H]MK-801结合水平均升高，在壳核中达到显著水平。
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