从乌黑白眉猴中克隆猴免疫缺陷病毒的分子克隆。
Molecular cloning of SIV from sooty mangabey monkeys.
作者信息
Hirsch V M, Dapolito G, McGann C, Olmsted R A, Purcell R H, Johnson P R
机构信息
Department of Microbiology, Georgetown University, Washington, DC.
出版信息
J Med Primatol. 1989;18(3-4):279-85.
PMID:2547963
Abstract
We derived two infectious molecular clones of SIV from sooty mangabey monkeys (Cercocebus atys) and compared them by restriction enzyme mapping and limited DNA sequencing to other known primate lentiviruses. These analyses show that SIVsmm is closely related to, but distinct from, SIVmac and HIV-2. Our data suggest that SIVmac may have been derived from SIVsmm by cross-species transmission in captivity.
摘要
我们从乌黑白眉猴（Cercocebus atys）中获得了两个SIV感染性分子克隆，并通过限制性酶切图谱分析和有限的DNA测序，将它们与其他已知的灵长类慢病毒进行了比较。这些分析表明，SIVsmm与SIVmac和HIV-2密切相关，但又有所不同。我们的数据表明，SIVmac可能是通过圈养环境中的跨物种传播从SIVsmm衍生而来的。
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