Stanford Cardiovascular Institute, Stanford, CA 94305, USA.
Stanford Cardiovascular Institute, Stanford, CA 94305, USA; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Cell Stem Cell. 2014 Dec 4;15(6):671-3. doi: 10.1016/j.stem.2014.11.008.
Preclinical and clinical studies for cardiac cell therapy have only seen moderate success due to poor engraftment and survival of transplanted cells. In this issue of Cell Stem Cell, Ye et al. (2014) employ a growth-factor-loaded fibrin patch and show improved cardiovascular cell survival after cell transplantation into a porcine model of ischemia reperfusion.
由于移植细胞的植入和存活效果不佳，心脏细胞治疗的临床前和临床研究仅取得了中等成效。在本期的《Cell Stem Cell》杂志上，叶等人（2014）采用了载有生长因子的纤维蛋白贴，并在猪缺血再灌注模型中进行细胞移植后，观察到心血管细胞的存活率得到了提高。
