From the University of Minnesota, Minneapolis.
Circ Res. 2013 Sep 13;113(7):922-32. doi: 10.1161/CIRCRESAHA.113.300216.
Transplantation of engineered tissue patches containing either progenitor cells or cardiomyocytes for cardiac repair is emerging as an exciting treatment option for patients with postinfarction left ventricular remodeling. The beneficial effects may evolve directly from remuscularization or indirectly through paracrine mechanisms that mobilize and activate endogenous progenitor cells to promote neovascularization and remuscularization, inhibit apoptosis, and attenuate left ventricular dilatation and disease progression. Despite encouraging results, further improvements are necessary to enhance current tissue engineering concepts and techniques and to achieve clinical impact. Herein, we review several strategies for cardiac remuscularization and paracrine support that can induce cardiac repair and attenuate left ventricular dysfunction from both within and outside the myocardium.
将含有祖细胞或心肌细胞的工程组织片移植到心脏修复中，为心肌梗死后左心室重构的患者提供了一种令人兴奋的治疗选择。其有益作用可能直接来自于再肌化，或间接通过旁分泌机制，动员和激活内源性祖细胞来促进血管新生和再肌化、抑制细胞凋亡、减轻左心室扩张和疾病进展。尽管取得了令人鼓舞的结果，但仍需要进一步改进，以增强现有的组织工程概念和技术，并实现临床效果。在此，我们综述了几种能够从心肌内外诱导心脏修复和减轻左心室功能障碍的心肌再肌化和旁分泌支持策略。
