热休克蛋白在固有免疫系统和适应性免疫系统途径中的功能。
Functions of heat shock proteins in pathways of the innate and adaptive immune system.
作者信息
Binder Robert Julian
机构信息
Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261
出版信息
J Immunol. 2014 Dec 15;193(12):5765-71. doi: 10.4049/jimmunol.1401417.
Abstract
For more than 50 years, heat shock proteins (HSPs) have been studied for their role in protecting cells from elevated temperature and other forms of stress. More recently, several roles have been ascribed to HSPs in the immune system. These include intracellular roles in Ag presentation and expression of innate receptors, as well as extracellular roles in tumor immunosurveillance and autoimmunity. Exogenously administered HSPs can elicit a variety of immune responses that have been used in immunotherapy of cancer, infectious diseases, and autoimmune disease.
摘要
五十多年来，人们一直在研究热休克蛋白（HSPs）在保护细胞免受高温和其他形式应激方面的作用。最近，HSPs在免疫系统中又被赋予了多种功能。这些功能包括在抗原呈递和天然受体表达方面的细胞内作用，以及在肿瘤免疫监视和自身免疫方面的细胞外作用。外源性给予的HSPs可引发多种免疫反应，这些反应已被用于癌症、传染病和自身免疫性疾病的免疫治疗。
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