热疗肿瘤学中热效应与非热效应的协同作用
The Synergy of Thermal and Non-Thermal Effects in Hyperthermic Oncology.
作者信息
Minnaar Carrie Anne, Szigeti Gyula Peter, Szasz Andras
机构信息
Department of Radiation Sciences, University of the Witwatersrand, Johannesburg 2000, South Africa.
John von Neumann Faculty of Informatics, Óbuda University, 1034 Budapest, Hungary.
出版信息
Cancers (Basel). 2024 Nov 21;16(23):3908. doi: 10.3390/cancers16233908.
BACKGROUND
Modulated electro-hyperthermia (mEHT) is unique due to its combination of thermal and non-thermal effects.
METHOD
This report summarizes the literature on the effects of mEHT observed in vitro and in vivo.
RESULTS
The thermal and electrical heterogeneity of tissues allows the radiofrequency signal to selectively target malignant tissue. The applied modulation appears to activate various apoptotic pathways, predominantly leading to immunogenic cell death (ICD). ICD promotes the release of damage-associated molecular patterns, potentially producing tumour-specific antigen-presenting cells. This abscopal-type effect may target distant metastases while treating the primary tumour locally. This immune memory effect is like vaccination mechanisms.
CONCLUSIONS
The application of mEHT has the potential to expand from local to systemic disease, enabling the simultaneous treatment of micro- and macro-metastases.
背景
调制式电超高温疗法（mEHT）因其热效应和非热效应的结合而独具特色。
方法
本报告总结了关于mEHT在体外和体内所观察到的效应的文献。
结果
组织的热和电不均匀性使射频信号能够选择性地靶向恶性组织。所施加的调制似乎激活了各种凋亡途径，主要导致免疫原性细胞死亡（ICD）。ICD促进损伤相关分子模式的释放，有可能产生肿瘤特异性抗原呈递细胞。这种远隔效应可能在局部治疗原发性肿瘤的同时靶向远处转移灶。这种免疫记忆效应类似于疫苗接种机制。
结论
mEHT的应用有可能从局部疾病扩展到全身疾病，从而能够同时治疗微转移和大转移。
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