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利用基因表达综合数据集探索骨关节炎中热休克蛋白相关生物标志物和亚组。

Exploring heat shock protein-related biomarkers and subgroups in osteoarthritis using Gene Expression Omnibus data sets.

作者信息

Cai Weixin, Yan Boxin, Song Hanbing, Liu Jiaxing, Wang Geqiang, Jiang Yichang

机构信息

Department of Orthopaedics and Traumatology III, The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, 26 Heping Road, Xiangfang District, Harbin, 150040, China.

Second Department of Gynaecology, The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, No. 411, Gogoli Street, Nangang District, Harbin, 150001, China.

出版信息

BMC Musculoskelet Disord. 2025 Jun 5;26(1):562. doi: 10.1186/s12891-025-08827-1.

DOI:10.1186/s12891-025-08827-1
PMID:40474128
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12139309/
Abstract

Osteoarthritis (OA) is a degenerative joint disease marked by cartilage deterioration. Recent studies suggest that heat shock proteins (HSPs) may play a role in the pathophysiology of OA. This study explores the role of heat shock protein-related genes (HSRs) in OA using GEO datasets (GSE12021, GSE55457, GSE55235). Differential expression analysis identified 34 HSRs with significant changes in OA. Protein-protein interaction (PPI) network analysis highlighted central HSRs, including HSPA5, HSPA6, HSPA1L, HSPA12 A, and HSPH1, indicating their key roles in OA. Enrichment analysis revealed that HSRs are involved in protein folding, chaperone activities, and endoplasmic reticulum stress. A nomogram developed from HSR expression profiles demonstrated high accuracy in predicting OA risk. Clustering analysis identified two distinct HSR-related subgroups with unique gene expression and immune profiles. Variations in immune cell infiltration and immune pathway activities were observed between these subgroups. Overall, the study underscores the significance of HSRs in OA pathogenesis and suggests potential personalized therapeutic strategies based on distinct HSR-related subgroups.

摘要

骨关节炎（OA）是一种以软骨退化为特征的退行性关节疾病。最近的研究表明，热休克蛋白（HSPs）可能在OA的病理生理学中发挥作用。本研究使用GEO数据集（GSE12021、GSE55457、GSE55235）探讨热休克蛋白相关基因（HSRs）在OA中的作用。差异表达分析确定了34个在OA中发生显著变化的HSRs。蛋白质-蛋白质相互作用（PPI）网络分析突出了核心HSRs，包括HSPA5、HSPA6、HSPA1L、HSPA12 A和HSPH1，表明它们在OA中的关键作用。富集分析显示，HSRs参与蛋白质折叠、伴侣活性和内质网应激。根据HSR表达谱开发的列线图在预测OA风险方面具有很高的准确性。聚类分析确定了两个不同的HSR相关亚组，它们具有独特的基因表达和免疫谱。在这些亚组之间观察到免疫细胞浸润和免疫途径活性的差异。总体而言，该研究强调了HSRs在OA发病机制中的重要性，并提出了基于不同HSR相关亚组的潜在个性化治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b66b/12139309/8ff636a4612c/12891_2025_8827_Fig9_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b66b/12139309/cb7248e3b894/12891_2025_8827_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b66b/12139309/8ff636a4612c/12891_2025_8827_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b66b/12139309/843494192801/12891_2025_8827_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b66b/12139309/d131ef865bad/12891_2025_8827_Fig3_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b66b/12139309/521ac1260a58/12891_2025_8827_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b66b/12139309/7e40a0d10c63/12891_2025_8827_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b66b/12139309/a827e979b3b4/12891_2025_8827_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b66b/12139309/cb7248e3b894/12891_2025_8827_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b66b/12139309/8ff636a4612c/12891_2025_8827_Fig9_HTML.jpg

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本文引用的文献

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Heme Metabolism-Related Gene TENT5C is a Prognostic Marker and Investigating Its Immunological Role in Colon Cancer.血红素代谢相关基因TENT5C是一种预后标志物及其在结肠癌中的免疫作用研究
Pharmgenomics Pers Med. 2023 Dec 23;16:1127-1143. doi: 10.2147/PGPM.S433790. eCollection 2023.
2
Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review.氧化应激作为调控骨关节炎和骨质疏松细胞命运的关键因素：一个叙述性综述。
Cell Mol Biol Lett. 2023 Sep 30;28(1):76. doi: 10.1186/s11658-023-00489-y.
3
Apoptosis Regulation in Osteoarthritis and the Influence of Lipid Interactions.
骨关节炎中的细胞凋亡调控及脂类相互作用的影响。
Int J Mol Sci. 2023 Aug 22;24(17):13028. doi: 10.3390/ijms241713028.
4
Development and assessment of a predictive model for early diagnosis of rheumatoid arthritis in southwest China: A new nomogram.开发和评估中国西南地区类风湿关节炎早期诊断的预测模型：一个新的列线图。
Medicine (Baltimore). 2023 Mar 24;102(12):e33386. doi: 10.1097/MD.0000000000033386.
5
The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest.2023 年的 STRING 数据库：针对任何感兴趣的测序基因组的蛋白质-蛋白质关联网络和功能富集分析。
Nucleic Acids Res. 2023 Jan 6;51(D1):D638-D646. doi: 10.1093/nar/gkac1000.
6
Obesity, Inflammation, and Immune System in Osteoarthritis.肥胖、炎症与骨关节炎的免疫系统。
Front Immunol. 2022 Jul 4;13:907750. doi: 10.3389/fimmu.2022.907750. eCollection 2022.
7
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Geroscience. 2021 Oct;43(5):2515-2532. doi: 10.1007/s11357-021-00394-2. Epub 2021 Jul 9.
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