心病毒和口疮病毒RNA 5'-非翻译区二级结构元件的保守性。
Conservation of the secondary structure elements of the 5'-untranslated region of cardio- and aphthovirus RNAs.
作者信息
Pilipenko E V, Blinov V M, Chernov B K, Dmitrieva T M, Agol V I
机构信息
Institute of Poliomyelitis and Viral Encephalitides, USSR Academy of Medical Sciences, Moscow.
出版信息
Nucleic Acids Res. 1989 Jul 25;17(14):5701-11. doi: 10.1093/nar/17.14.5701.
Abstract
An analysis of published nucleotide sequences of the 5'-untranslated region (5'-UTR) of 7 cardioviruses and 3 aphthoviruses has allowed us to derive a consensus secondary structure model that differs from that previously proposed for the 5'-UTR of entero- and rhinoviruses, though all these viruses belong to the same family, Picornaviridae. The theoretical model derived here was experimentally supported by investigating the accessibility of encephalomyocarditis virus RNA to modifications with dimethyl sulfate and its susceptibility to S1 and cobra venom nucleases. The possible involvement of the 5"-UTR secondary structure domains in the translational control is briefly discussed.
摘要
对7种心病毒和3种口蹄疫病毒的5'-非翻译区（5'-UTR）已发表的核苷酸序列进行分析后，我们得出了一个共有二级结构模型，该模型与先前针对肠道病毒和鼻病毒5'-UTR所提出的模型不同，尽管所有这些病毒都属于同一科——小核糖核酸病毒科。通过研究脑心肌炎病毒RNA对硫酸二甲酯修饰的可及性及其对S1核酸酶和眼镜蛇毒核酸酶的敏感性，本文推导的理论模型得到了实验支持。文中还简要讨论了5'-UTR二级结构域在翻译控制中的可能作用。
相似文献
1
Conservation of the secondary structure elements of the 5'-untranslated region of cardio- and aphthovirus RNAs.心病毒和口疮病毒RNA 5'-非翻译区二级结构元件的保守性。
Nucleic Acids Res. 1989 Jul 25;17(14):5701-11. doi: 10.1093/nar/17.14.5701.
2
Gross rearrangements within the 5'-untranslated region of the picornaviral genomes.微小核糖核酸病毒基因组5'非翻译区内的大片段重排。
Nucleic Acids Res. 1990 Jun 11;18(11):3371-5. doi: 10.1093/nar/18.11.3371.
3
Conserved structural domains in the 5'-untranslated region of picornaviral genomes: an analysis of the segment controlling translation and neurovirulence.小核糖核酸病毒基因组5'非翻译区的保守结构域：对控制翻译和神经毒力片段的分析
Virology. 1989 Feb;168(2):201-9. doi: 10.1016/0042-6822(89)90259-6.
4
The primary and secondary structure of the 5'-end region of encephalomyocarditis virus RNA. A novel approach to sequencing long RNA molecules.脑心肌炎病毒RNA 5'端区域的一级和二级结构。一种测序长RNA分子的新方法。
Gene. 1983 Dec;26(2-3):189-95. doi: 10.1016/0378-1119(83)90189-0.
5
An initiation signal in the 5' untranslated leader sequence of encephalomyocarditis virus RNA.
Biochim Biophys Acta. 1990 Aug 27;1050(1-3):124-8. doi: 10.1016/0167-4781(90)90152-r.
6
7
Conserved tertiary structural elements in the 5' nontranslated region of cardiovirus, aphthovirus and hepatitis A virus RNAs.心病毒、口疮病毒和甲型肝炎病毒RNA 5'非翻译区中保守的三级结构元件。
Nucleic Acids Res. 1993 May 25;21(10):2445-51. doi: 10.1093/nar/21.10.2445.
8
RNA--protein interactions within the internal translation initiation region of encephalomyocarditis virus RNA.脑心肌炎病毒RNA内部翻译起始区域内的RNA-蛋白质相互作用。
Nucleic Acids Res. 1991 Sep 25;19(18):4999-5005. doi: 10.1093/nar/19.18.4999.
9
The 5'-terminal region of the Aichi virus genome encodes cis-acting replication elements required for positive- and negative-strand RNA synthesis.爱知病毒基因组的5'末端区域编码正链和负链RNA合成所需的顺式作用复制元件。
J Virol. 2005 Jun;79(11):6918-31. doi: 10.1128/JVI.79.11.6918-6931.2005.
10
[The nucleotide sequence of the 3'-terminal region of encephalomyocarditis virus RNA].[脑心肌炎病毒RNA 3'末端区域的核苷酸序列]
Bioorg Khim. 1983 Jul;9(7):986-9.
引用本文的文献
1
: neglected for too long?被忽视太久了？
J Virol. 2025 Apr 15;99(4):e0184624. doi: 10.1128/jvi.01846-24. Epub 2025 Mar 25.
2
Translation of Overlapping Open Reading Frames Promoted by Type 2 IRESs in Avian Calicivirus Genomes.翻译：2 型内部核糖体进入位点在禽呼肠孤病毒基因组中促进重叠开放阅读框。
Viruses. 2024 Sep 4;16(9):1413. doi: 10.3390/v16091413.
3
Validating the EMCV IRES Secondary Structure with Structure-Function Analysis.用结构功能分析验证 EMCV IRES 二级结构。
Biochemistry. 2024 Jan 2;63(1):107-115. doi: 10.1021/acs.biochem.3c00579. Epub 2023 Dec 11.
4
Chemical and Enzymatic Probing of Viral RNAs: From Infancy to Maturity and Beyond.病毒 RNA 的化学和酶探针：从婴儿期到成熟期及以后。
Viruses. 2021 Sep 22;13(10):1894. doi: 10.3390/v13101894.
5
Non-Canonical Translation Initiation Mechanisms Employed by Eukaryotic Viral mRNAs.真核病毒 mRNA 所采用的非经典翻译起始机制。
Biochemistry (Mosc). 2021 Sep;86(9):1060-1094. doi: 10.1134/S0006297921090042.
6
Translational Control of the Picornavirus Phenotype.微小核糖核酸病毒表型的翻译控制
Mol Biol. 2001;35(4):591-599. doi: 10.1023/A:1010531228348.
7
Heterogeneous Nuclear Ribonucleoprotein L Negatively Regulates Foot-and-Mouth Disease Virus Replication through Inhibition of Viral RNA Synthesis by Interacting with the Internal Ribosome Entry Site in the 5' Untranslated Region.异质核核糖核蛋白 L 通过与 5'非翻译区内部核糖体进入位点相互作用抑制病毒 RNA 合成来负调控口蹄疫病毒复制。
J Virol. 2020 May 4;94(10). doi: 10.1128/JVI.00282-20.
8
A conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites.一种保守的 RNA 结构基序，用于组织小核糖核酸病毒内部核糖体进入位点的拓扑结构。
Nat Commun. 2019 Aug 9;10(1):3629. doi: 10.1038/s41467-019-11585-z.
9
The Pseudoknot Region of the 5' Untranslated Region Is a Determinant of Viral Tropism and Virulence of Foot-and-Mouth Disease Virus.5' 非翻译区的假结区是决定口蹄疫病毒嗜性和毒力的决定因素。
J Virol. 2019 Apr 3;93(8). doi: 10.1128/JVI.02039-18. Print 2019 Apr 15.
10
Emergency Services of Viral RNAs: Repair and Remodeling.病毒 RNA 的应急服务：修复与重塑。
Microbiol Mol Biol Rev. 2018 Mar 14;82(2). doi: 10.1128/MMBR.00067-17. Print 2018 Jun.
本文引用的文献
1
The nucleotide and deduced amino acid sequences of the encephalomyocarditis viral polyprotein coding region.脑心肌炎病毒多聚蛋白编码区的核苷酸序列及推导的氨基酸序列。
Nucleic Acids Res. 1984 Mar 26;12(6):2969-85. doi: 10.1093/nar/12.6.2969.
2
Nucleotide sequence and genome organization of foot-and-mouth disease virus.口蹄疫病毒的核苷酸序列与基因组结构
Nucleic Acids Res. 1984 Aug 24;12(16):6587-601. doi: 10.1093/nar/12.16.6587.
3
Simple method for the isolation of encephalomyocarditis virus ribonucleic acid.分离脑心肌炎病毒核糖核酸的简易方法。
J Virol. 1972 Mar;9(3):559-61. doi: 10.1128/JVI.9.3.559-561.1972.
4
Poliovirus polypeptide precursors: expression in vitro and processing by exogenous 3C and 2A proteinases.脊髓灰质炎病毒多肽前体：体外表达及外源性3C和2A蛋白酶的加工处理
Proc Natl Acad Sci U S A. 1987 Jun;84(12):4002-6. doi: 10.1073/pnas.84.12.4002.
5
Effects of cDNA hybridization on translation of encephalomyocarditis virus RNA.互补DNA杂交对脑心肌炎病毒核糖核酸翻译的影响。
J Virol. 1987 Jun;61(6):2033-7. doi: 10.1128/JVI.61.6.2033-2037.1987.
6
Analysis of the complete nucleotide sequence of the picornavirus Theiler's murine encephalomyelitis virus indicates that it is closely related to cardioviruses.微小核糖核酸病毒泰勒氏鼠脑脊髓炎病毒的完整核苷酸序列分析表明，它与心病毒密切相关。
J Virol. 1987 May;61(5):1507-16. doi: 10.1128/JVI.61.5.1507-1516.1987.
7
The genomes of attenuated and virulent poliovirus strains differ in their in vitro translation efficiencies.减毒和毒性脊髓灰质炎病毒株的基因组在体外翻译效率上存在差异。
Virology. 1985 Dec;147(2):243-52. doi: 10.1016/0042-6822(85)90127-8.
8
Nucleotide and amino acid sequence coding for polypeptides of foot-and-mouth disease virus type A12.编码A12型口蹄疫病毒多肽的核苷酸和氨基酸序列
J Virol. 1985 Jun;54(3):651-60. doi: 10.1128/JVI.54.3.651-660.1985.
9
Comparison of the nucleotide sequences of diabetogenic and nondiabetogenic encephalomyocarditis virus.致糖尿病性与非致糖尿病性脑心肌炎病毒核苷酸序列的比较。
Virology. 1988 Oct;166(2):603-7. doi: 10.1016/0042-6822(88)90534-x.
10
Point mutations modify the response of poliovirus RNA to a translation initiation factor: a comparison of neurovirulent and attenuated strains.点突变改变脊髓灰质炎病毒RNA对翻译起始因子的反应：神经毒力株与减毒株的比较
Virology. 1988 Oct;166(2):394-404. doi: 10.1016/0042-6822(88)90510-7.
Zotero 插件