一种调控植物线粒体mRNA聚腺苷酸化状态和稳定性的独特系统。
A unique system for regulating mitochondrial mRNA poly(A) status and stability in plants.
作者信息
Hirayama Takashi
机构信息
a Institute of Plant Science and Resources ; Okayama University ; Okayama , Japan.
出版信息
Plant Signal Behav. 2014;9(10):e973809. doi: 10.4161/15592324.2014.973809.
Abstract
Poly(A) status is the major determinant of mRNA stability, even in endosymbiotic organelles. Poly(A) specific ribonuclease (PARN) is distributed widely among eukaryotes and has been shown to regulate the poly(A) status of cytoplasmic mRNA in various organisms. Surprisingly, our recent study revealed that PARN also directly regulates poly(A) status of mitochondrial mRNA in Arabidopsis. In this addendum, we discuss whether this mitochondrial function of PARN is common in plants and why PARN has been assigned such a unique function.
摘要
聚腺苷酸化（Poly(A)）状态是信使核糖核酸（mRNA）稳定性的主要决定因素，即使在细胞内共生细胞器中也是如此。聚腺苷酸特异性核糖核酸酶（PARN）广泛分布于真核生物中，并已证明在各种生物体中调节细胞质mRNA的聚腺苷酸化状态。令人惊讶的是，我们最近的研究表明，PARN在拟南芥中还直接调节线粒体mRNA的聚腺苷酸化状态。在本附录中，我们讨论PARN的这种线粒体功能在植物中是否普遍存在，以及为什么PARN被赋予了这样一种独特的功能。
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