miR-23a 和 miR-125b 通过靶向 Musashi1 调节神经干细胞/祖细胞增殖。
Mir-23a and mir-125b regulate neural stem/progenitor cell proliferation by targeting Musashi1.
机构信息
a Deptartment of Biology and Biotechnology Charles Darwin ; Sapienza University of Rome ; Rome, Italy.
出版信息
RNA Biol. 2014;11(9):1105-12. doi: 10.4161/rna.35508.
Abstract
Musashi1 is an RNA binding protein that controls the neural cell fate, being involved in maintaining neural progenitors in their proliferative state. In particular, its downregulation is needed for triggering early neural differentiation programs. In this study, we profiled microRNA expression during the transition from neural progenitors to differentiated astrocytes and underscored 2 upregulated microRNAs, miR-23a and miR-125b, that sinergically act to restrain Musashi1 expression, thus creating a regulatory module controlling neural progenitor proliferation.
摘要
Musashi1 是一种 RNA 结合蛋白，可控制神经细胞命运，参与维持神经祖细胞的增殖状态。特别是，下调 Musashi1 对于触发早期神经分化程序是必需的。在这项研究中，我们对神经祖细胞向分化的星形胶质细胞过渡过程中的 microRNA 表达进行了分析，并强调了 2 个上调的 microRNA，miR-23a 和 miR-125b，它们协同作用抑制 Musashi1 的表达，从而形成一个调控模块来控制神经祖细胞的增殖。
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