美国的获许可的百日咳疫苗。历史与现状。
Licensed pertussis vaccines in the United States. History and current state.
作者信息
Klein Nicola P
机构信息
a Kaiser Permanente Vaccine Study Center ; Oakland , CA USA.
出版信息
Hum Vaccin Immunother. 2014;10(9):2684-90. doi: 10.4161/hv.29576. Epub 2014 Nov 6.
Abstract
The United States switched from whole cell to acellular pertussis vaccines in the 1990s following global concerns with the safety of the whole cell vaccines. Despite high levels of acellular pertussis vaccine coverage, the United States and other countries are experiencing large pertussis outbreaks. The aim of this article is to describe the historical context which led to acellular pertussis vaccine development, focusing on vaccines currently licensed in the US, and to review evidence that waning protection following licensed acellular pertussis vaccines have been significant factors in the widespread reappearance of pertussis.
摘要
20世纪90年代，在全球对全细胞疫苗安全性表示担忧之后，美国从全细胞百日咳疫苗转向了无细胞百日咳疫苗。尽管无细胞百日咳疫苗的接种率很高，但美国和其他国家仍在经历大规模的百日咳疫情。本文的目的是描述导致无细胞百日咳疫苗研发的历史背景，重点关注美国目前已获许可的疫苗，并审查证据，证明已获许可的无细胞百日咳疫苗接种后保护作用减弱是百日咳广泛再现的重要因素。
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