氧化应激作为添加糖诱发心血管疾病的一种机制。
Oxidative stress as a mechanism of added sugar-induced cardiovascular disease.
作者信息
Prasad Kailash, Dhar Indu
机构信息
Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
出版信息
Int J Angiol. 2014 Dec;23(4):217-26. doi: 10.1055/s-0034-1387169.
Added sugars comprising of table sugar, brown sugar, corn syrup, maple syrup, honey, molasses, and other sweeteners in the prepared processed foods and beverages have been implicated in the pathophysiology of cardiovascular diseases. This article deals with the reactive oxygen species (ROS) as a mechanism of sugar-induced cardiovascular diseases. There is an association between the consumption of high levels of serum glucose with cardiovascular diseases. Various sources of sugar-induced generation of ROS, including mitochondria, nicotinamide adenine dinucleotide phosphate-oxidase, advanced glycation end products, insulin, and uric acid have been discussed. The mechanism by which ROS induce the development of atherosclerosis, hypertension, peripheral vascular disease, coronary artery disease, cardiomyopathy, heart failure, and cardiac arrhythmias have been discussed in detail. In conclusion, the data suggest that added sugars induce atherosclerosis, hypertension, peripheral vascular disease, coronary artery disease, cardiomyopathy, heart failure, and cardiac arrhythmias and that these effects of added sugars are mediated through ROS.
预制加工食品和饮料中含有的添加糖，包括食糖、红糖、玉米糖浆、枫糖浆、蜂蜜、糖蜜及其他甜味剂，与心血管疾病的病理生理机制有关。本文探讨了活性氧（ROS）作为糖诱导心血管疾病的一种机制。血清葡萄糖水平过高与心血管疾病之间存在关联。文中讨论了糖诱导ROS产生的各种来源，包括线粒体、烟酰胺腺嘌呤二核苷酸磷酸氧化酶、晚期糖基化终产物、胰岛素和尿酸。文中详细讨论了ROS诱导动脉粥样硬化、高血压、外周血管疾病、冠状动脉疾病、心肌病、心力衰竭和心律失常发展的机制。总之，数据表明添加糖会诱发动脉粥样硬化、高血压、外周血管疾病、冠状动脉疾病、心肌病、心力衰竭和心律失常，且添加糖的这些作用是通过ROS介导的。
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