Institut de Biología Molecular de Barcelona, CSIC, Parc Científic de Barcelona, Baldiri i Reixac 15, 08028-Barcelona, Spain.
Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India.
IUCrJ. 2014 Oct 14;1(Pt 6):492-504. doi: 10.1107/S205225251402003X. eCollection 2014 Nov 1.
For more than 30 years X-ray crystallography has been by far the most powerful approach for determining the structures of viruses and viral proteins at atomic resolution. The information provided by these structures, which covers many important aspects of the viral life cycle such as cell-receptor recognition, viral entry, nucleic acid transfer and genome replication, has extensively enriched our vision of the virus world. Many of the structures available correspond to potential targets for antiviral drugs against important human pathogens. This article provides an overview of the current knowledge of different structural aspects of the above-mentioned processes.
三十多年来，X 射线晶体学一直是确定病毒和病毒蛋白原子分辨率结构的最有力方法。这些结构提供了许多有关病毒生命周期的重要方面的信息，例如细胞受体识别、病毒进入、核酸转移和基因组复制，极大地丰富了我们对病毒世界的认识。许多现有的结构对应于针对重要人类病原体的抗病毒药物的潜在靶标。本文概述了上述过程不同结构方面的现有知识。
