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感染猴免疫缺陷病毒（SIVmac 251）后恒河猴的尿新蝶呤浓度

Urinary neopterin concentrations in rhesus monkeys after infection with simian immunodeficiency virus (SIVmac 251).

作者信息

Fendrich C, Lüke W, Stahl-Hennig C, Herchenröder O, Fuchs D, Wachter H, Hunsmann G

机构信息

Deutsches Primatenzentrum GmbH, Göttingen, Federal Republic of Germany.

出版信息

AIDS. 1989 May;3(5):305-7. doi: 10.1097/00002030-198905000-00010.

DOI:10.1097/00002030-198905000-00010
PMID:2548536
Abstract

Two rhesus monkeys were infected with SIVmac 251. Elevated urinary neopterin concentrations were observed as the first sign of infection. Virus-specific antibodies were detected 14 days after infection, when neopterin concentrations were already decreasing. The neopterin levels of one animal remained elevated and the virus was repeatedly isolated. Urinary or serum neopterin concentrations appear to be early markers for SIV infection and viremia in rhesus monkeys.

摘要

两只恒河猴感染了SIVmac 251。尿新蝶呤浓度升高是感染的首个迹象。感染14天后检测到病毒特异性抗体，此时新蝶呤浓度已在下降。其中一只动物的新蝶呤水平持续升高，且病毒被反复分离出来。尿或血清新蝶呤浓度似乎是恒河猴感染SIV和病毒血症的早期标志物。

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