阿曲库铵对神经肌肉阻滞的自动控制。

Automatic control of neuromuscular block with atracurium.

作者信息

MacLeod A D, Asbury A J, Gray W M, Linkens D A

机构信息

Department of Anaesthetics, Victoria Infirmary, Glasgow.

出版信息

Br J Anaesth. 1989 Jul;63(1):31-5. doi: 10.1093/bja/63.1.31.

DOI:10.1093/bja/63.1.31

PMID:2548549

Abstract

We have developed and tested a system for providing automatic control of neuromuscular block with atracurium. The degree of neuromuscular block was monitored in the small muscles of the hand using a Datex Relaxograph, and the signal was used as the controlled variable for a proportional plus integral controller. A preloaded integral was used to shorten the period of stabilization. The system was tested in 36 patients undergoing surgery and found to produce stable block. For a target T1 of 20% of control value, the mean block was 18.7 (SD 1.3) % of baseline T1 and the mean consumption of atracurium was 5.39 (SD 1.23) micrograms kg-1 min-1. The block was sufficiently stable to act as a background for studies of pharmacological and physiological interactions with atracurium.

摘要

我们已经研发并测试了一种用于自动控制阿曲库铵神经肌肉阻滞的系统。使用Datex Relaxograph对手部小肌肉的神经肌肉阻滞程度进行监测，该信号用作比例积分控制器的控制变量。采用预加载积分来缩短稳定期。该系统在36例接受手术的患者中进行了测试，发现能产生稳定的阻滞效果。对于目标T1为对照值的20%，平均阻滞为基线T1的18.7（标准差1.3）%，阿曲库铵的平均消耗量为5.39（标准差1.23）微克·千克⁻¹·分钟⁻¹。该阻滞足够稳定，可作为研究与阿曲库铵的药理和生理相互作用的背景。