Van Elsacker-Niele A M, Salimans M M, Weiland H T, Vermey-Keers C, Anderson M J, Versteeg J
Department of Virology, University of Leiden, The Netherlands.
Br J Obstet Gynaecol. 1989 Jul;96(7):768-75. doi: 10.1111/j.1471-0528.1989.tb03314.x.
In a current Netherlands study on the effects on mother and child of infection with the human parvovirus B19 during pregnancy, 10 pregnancies have been reported. Three of them ended before term: two in fetal death and one by elective abortion. In two of these fetuses B19 infection in cells other than those of the erythroid series was demonstrated, and in the one terminated, ocular malformation and extensive inflammatory reactions in all fetal and placental tissues were found. The presence of B19 DNA was demonstrated by dot hybridization in placental and fetal tissues. In the third no gross fetal abnormalities were found, although B19 DNA was detected in several fetal tissues by in-situ hybridization. Of the remaining seven pregnancies, six ended at term in the birth of apparently healthy babies. The other child was born near term with a low birthweight and multiple congenital malformations, but with no proof of intrauterine B19 infection. It is concluded that B19 infection in pregnancy can interfere with organ development and may lead to intrauterine fetal death.
在荷兰目前一项关于孕期感染人细小病毒B19对母婴影响的研究中，已报告了10例妊娠情况。其中3例早产：2例胎儿死亡，1例选择性流产。在其中2例胎儿中，除红系细胞外的其他细胞中证实有B19感染，而在1例终止妊娠的胎儿中，发现眼部畸形以及所有胎儿和胎盘组织中有广泛的炎症反应。通过斑点杂交在胎盘和胎儿组织中证实了B19 DNA的存在。第3例未发现明显的胎儿异常，尽管通过原位杂交在多个胎儿组织中检测到了B19 DNA。其余7例妊娠中，6例足月分娩出明显健康的婴儿。另一个婴儿早产，出生体重低且有多种先天性畸形，但没有宫内B19感染的证据。研究得出结论，孕期B19感染可干扰器官发育，并可能导致宫内胎儿死亡。
