D'Souza Nigel, Nugent Karen
Wessex Deanery, UK.
BMJ Clin Evid. 2014 Dec 8;2014:0408.
Appendicitis is an inflammation of the appendix that may lead to an abscess, ileus, peritonitis, or death if untreated. Appendicitis is the most common abdominal surgical emergency. The current standard treatment of uncomplicated appendicitis is usually surgery, but there has been increasing evidence published on the use of antibiotics.
We conducted a systematic review and aimed to answer the following clinical question: What are the effects of surgery compared with antibiotics for acute appendicitis? We searched: Medline, Embase, The Cochrane Library, and other important databases up to May 2014 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
We found four studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
In this systematic review we present information relating to the effectiveness and safety of surgery (including laparoscopic and open appendicectomy) compared with antibiotics.
阑尾炎是阑尾的炎症，如果不治疗可能会导致脓肿、肠梗阻、腹膜炎或死亡。阑尾炎是最常见的腹部外科急症。目前，单纯性阑尾炎的标准治疗通常是手术，但关于使用抗生素的证据越来越多。
我们进行了一项系统评价，旨在回答以下临床问题：与抗生素相比，手术治疗急性阑尾炎的效果如何？我们检索了：截至2014年5月的医学期刊数据库（Medline）、荷兰医学文摘数据库（Embase）、考克兰图书馆及其他重要数据库（临床证据综述会定期更新；请查看我们的网站获取本综述的最新版本）。我们纳入了来自美国食品药品监督管理局（FDA）和英国药品和医疗产品监管局（MHRA）等相关组织的危害警示。
我们发现四项符合纳入标准的研究。我们对干预措施的证据质量进行了GRADE评估。
在本系统评价中，我们提供了与手术（包括腹腔镜阑尾切除术和开腹阑尾切除术）和抗生素相比的有效性和安全性相关的信息。
