da Silva Bastos Valeria de Abreu, Freitas-Fernandes Liana Bastos, Fidalgo Tatiana Kelly da Silva, Martins Carla, Mattos Cláudia Trindade, de Souza Ivete Pomarico Ribeiro, Maia Lucianne Cople
Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Department of Dental Clinics, School of Dentistry, Universidade Federal Fluminense, Niterói, Brazil.
J Dent. 2015 Feb;43(2):181-91. doi: 10.1016/j.jdent.2014.12.001. Epub 2014 Dec 6.
A systematic review was performed with the aim of determining whether there is scientific evidence of the transmission of Streptococcus mutans from mother to child.
The eligibility criteria, based on the PECO strategy, were the following: observational human studies whose subjects were mother and child pairs (P) contaminated by S. mutans (E); comparison according to the presence or absence of S. mutans (C); and whether there is transmission (O). The qualitative analysis was performed by assessing the risk of bias of the included studies, while quantitative synthesis was performed through comprehensive Meta-Analysis software (p<0.05).
Two reviewers performed the database search of studies published between January 1950 and May 2014. The strategy included observational studies that assessed the vertical transmission of S. mutans from mothers to children through analyzing genetic strains.
It was found 166 non-duplicated studies. However, after reviewing the articles in full and applying the eligibility criteria, 36 papers were selected for qualitative analysis and 19 for quantitative analysis. The cumulative meta-analysis demonstrated vertical transmission of S. mutans from mother to child (p<0.001).
The present systematic review and meta-analysis demonstrated evidence of vertical transmission of S. mutans from mother to child because there was an association between S. mutans n mothers and their respective children.
The knowledge of the S. mutans strains is important because the virulence of the microorganisms is varied; also, the virulence affects the dental caries evolution rate, being more or less aggressive.
进行一项系统评价，以确定是否有科学证据支持变形链球菌可从母亲传播给孩子。
基于PECO策略的纳入标准如下：以人为研究对象的观察性研究，其研究对象为受变形链球菌污染的母婴对（P）；根据是否存在变形链球菌进行比较（C）；以及是否存在传播（O）。通过评估纳入研究的偏倚风险进行定性分析，同时通过综合Meta分析软件进行定量合成（p<0.05）。
两名研究者对1950年1月至2014年5月发表的研究进行了数据库检索。检索策略包括通过分析基因菌株评估变形链球菌从母亲到孩子垂直传播的观察性研究。
共找到166项非重复研究。然而，在全面阅读文章并应用纳入标准后，选择了36篇论文进行定性分析，19篇进行定量分析。累积Meta分析表明变形链球菌可从母亲垂直传播给孩子（p<0.001）。
本系统评价和Meta分析证明了变形链球菌可从母亲垂直传播给孩子，因为母亲体内的变形链球菌与其孩子体内的变形链球菌之间存在关联。
了解变形链球菌菌株很重要，因为微生物的毒力各不相同；此外，毒力会影响龋齿的发展速度，其侵袭性有强有弱。
