Lu Yi, Liu Tingting, Lamanda Ariana C, Sin Mandy L Y, Gau Vincent, Liao Joseph C, Wong Pak Kin
Department of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, AZ, USA.
Biomedical Engineering, The University of Arizona, Tucson, AZ, USA.
J Lab Autom. 2015 Dec;20(6):611-20. doi: 10.1177/2211068214560904. Epub 2014 Dec 8.
Alternating current (AC) electrokinetics is a collection of processes for manipulating bulk fluid mass and embedded objects with AC electric fields. The ability of AC electrokinetics to implement the major microfluidic operations, such as pumping, mixing, concentration, and separation, makes it possible to develop integrated systems for clinical diagnostics in nontraditional health care settings. The high conductivity of physiological fluids presents new challenges and opportunities for AC electrokinetics-based diagnostic systems. In this review, AC electrokinetic phenomena in conductive physiological fluids are described followed by a review of the basic microfluidic operations and the recent biomedical applications of AC electrokinetics. The future prospects of AC electrokinetics for clinical diagnostics are presented.
交流电（AC）电动学是利用交流电场操纵大量流体物质和嵌入物体的一系列过程。交流电电动学具备实现诸如泵送、混合、浓缩和分离等主要微流控操作的能力，这使得在非传统医疗保健环境中开发用于临床诊断的集成系统成为可能。生理流体的高导电性给基于交流电电动学的诊断系统带来了新的挑战和机遇。在本综述中，首先描述了导电生理流体中的交流电动力学现象，接着回顾了基本的微流控操作以及交流电电动学在生物医学方面的最新应用。最后介绍了交流电电动学在临床诊断方面的未来前景。
